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msk 2 final df > kruse drugs > Flashcards

kruse drugs Flashcards

1
Q

adverse effects of imiquimod

A

inflamation, itching, redness, eriosion

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2
Q

moa acyclovir and other ovirs

A

converted to active triphosphat metabolites and inhibit DNA and RNA syn

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3
Q

benzoyl peroxide fights

A

anerobic bacteria

p acnes

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4
Q

topical antibacterial preps

A 
bacitracin
mupirocin
retapamulin
polymxin b sulfate
neomycin

BMR pulls nookie

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5
Q

pegylated interferon for what

A

stage II adjuvant therapy node positive melanoma pts

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6
Q

terbinafine accumulates where and treats what

A

skin, nail, fat

tinea corporis, capitis and onychomycosis

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7
Q

first gen H1 receptor antagonist

A

diphenhyrdramine and promethazine

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8
Q

ae fluorouracil (topical)

A

pain, pruritus, burning, hyperpigmentation

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9
Q

what has MOA of reducing sebaceious gland size and sebum production

AE?

A

isotretinoin

very dry skin and hypervitaminosis

severe acne

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10
Q

fluorouracil moa and treats

A

treats actinic keratoses

inhibits thmidylate synthetase and stops DNA and RNA synthesis

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11
Q

moa cyclosporin and AE

A

inhibits calcineurin which stop txn of IL-1 and 2 and T cell activation

AE: gingival hyperplasia, hirtuism, hypertension nephrotox hepatotox

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12
Q

azoles moa

A

inhibits fungal p450 = no ergosterol

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13
Q

MOA of allylaines

treats?

A

“fines”
inhibit squalene epoxidase, enzyme for ergosterol biosyn

tinea corporis, tinea cruris, tinea pedis

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14
Q

adapalene for

A

acne

tene lene acne fighting machine

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15
Q

AE vorinostat and romidepsin

A 
PE
DVT
GI
Anemia
Thrombocytopenia
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16
Q

ustekinumab moa

A

stops IL12 and IL23

possible CV events

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17
Q

griseofulvin treats

moa

A

dermatophyte infections

prevents mitosis of fungal cells

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18
Q

vismodegib treats

A

bcc by inhibiting shh

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19
Q

when do you stop alefacept

A

when CD4 gets under 250

dont give to pts with infection

20
Q

ciclopirox is a ___ agent

A

antifungal agent

21
Q

topical therapy for psoriasis

A 
emollients
corticosteroids
vitamin D analogs
tar 
tazarotene
calcineurin inhibitors
22
Q

nystatin treats

A

thrush

23
Q

what is used for kaposi sarcoma

A

alitretinoin

24
Q

moa methotrexate

A

inhitbits dihydrofolate reductase

25
Q

salicyclic acid treats what

A 
acne
seborrheic dermatitis
psoriasis 
hyperkeratosis
(PASH the salty acid)
26
Q

allylamines- ____

A

terbinafine
butenafine
naftifine

27
Q

systemic therapy psoriais

A 
methotrexate
cyclosporin
acitretin
alefacept
tnf inhibs
ustekinumab
28
Q

ciclopirox moa

A

prevents uptake of precursors for macromolecule syn

29
Q

AE vismodegib

A

dysguesia (abnormal taste), alopecia, fatigue, spasms

30
Q

tazarotene for

A

acne and psoriasis

tene lene acne fighting machine

31
Q

mupirocin moa

A

inhibit protein syn, binds bacterial isoleucyl tRNA synthetase

32
Q

tolnaftate treats what but not what

A

cutaneous mycoses: tinea pedis, corporis, cruris

not candida

33
Q

AE limus drugs

A

hyperlipidemia, hypertension, hyperglycemia, GI, neuro and neprhotox

itching buring red

34
Q

bexarotene for

AE?

A

CTCL

check cholesterol levels

35
Q

retapamulin MOA

treats

A

binds 50s subunit, fights staph and strep

36
Q

bacitracin and gramcidin MOA

A

inhibit cell wall syn

37
Q

absorbance order

A

tincture>wet dress>lotion >Gel>aerosol>Powder Pastes>cream>ointment

38
Q

BRAF inhibitors

for what?

A

vemurafenib
dabrafenib
trametibin

melanoma

39
Q

tacrolimus and pimecrolimus treats and MOA

A

moa stops T cell activation

treats atopic dermatitis and psoriasis

40
Q

imiquimod treats

A

external genital and perianal warts in adults
basal cell carcinoma
actinic keratosis

41
Q

AE salicyclic acid

A

nausea, vomiting, dizziness, loss of hearing, tinnitus

42
Q

what is ipilimumab moa and used for

A

blocks CTLA4 for metastatic melonoma

43
Q

second gen H1 receptor antag

A

zines and dines

non sedating bc don’t cross BBB

44
Q

azelaic acid treats what and moa

A

p acnes

stops testosterone to DHT

45
Q

neomycin and ___
moa
treats

A

inhibits protein syn and gentamicin

gram neg

46
Q

polymyxin B sulfate MOA

treats

A

increase permeability of cell wall and fights gram neg

47
Q

vorinostat and romidepsin for what

A

CTCL that is persistent or recurrent

msk 2 final df (10 decks)

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