test 7 biguanides

Question 1

Biguanides

Answer 1

• Biguanides (metformin) are classified as insulin sensitizers.
• Metformin increases glucose uptake and use by tissues

Question 2

Biguanides (Metformin) Mechanism of action

Answer 2

• Reduces glucose production by the liver
- important effect because hepatic glucose production is elevated in type 2 diabetes, contributing to hyperglycemia
• Decreases intestinal absorption of glucose
• Increases peripheral utilization.
• Metformin may be used alone or in combination with other oral agents or insulin