test 7 prostaglandin analogues

Question 1

PGE1 can be used for

Answer 1

o erectile dysfunction (by smooth muscle relaxation), or the keep the ductus arteriosus open until surgery, allowing time for correction

Question 2

Alprostadil (Muse, Caverject)

Answer 2

o PGE1 analogue
o This PGE1
is produced in seminal vesicles, erectile tissue, placenta, and ductus arteriosus of the fetus

Question 3

Lubiprostone

Answer 3

o PGE1 analogue
o used for the treatment of idiopathic constipation, opioid-induced constipation, and IBS constipation. It activates chloride channels in the intestine, leading fluid secretion

Question 4

Misoprostol (Cytotec)

Answer 4

o PGE1 analogue
o used to protect the mucosal ling of the stomach during chronic NSAID treatment. It binds to a prostaglandin receptor on parietal cells, reducing gastric acid release. Stimulates mucous production.
o Used off-label for induction of labor, by stimulating uterine contractions.

Question 5

Bimatoprost (Latisse, Lumigan)

Answer 5

o PGF2α analogue

o It is an ocular hypotensive agent and decreases intraocular pressure. Also increases eyelash length and prominence.