Paget's Disease of the Bone

Question 1

How do most patients present?

Answer 1

Most patients are asymptomatic

but pain can occur

Question 2

what bone cell is diseased in Paget’s

Answer 2

Osteoclast physiology is altered…they are hypersensitive to vitamin D. Too much bone remodeling occuring

Question 3

Genetic component of Paget’s

Answer 3

SQSTM1

Question 4

What are the stages of Paget Disease

Answer 4

1. Osteolytic stage (lots of resorption)
2. Mixed stage(osteoblast activity dominates)
3. Osteosclerotic phase (burnt out and overworked)

Question 5

Histological organization of bone in Paget

Answer 5

Jigsaw/Mosaic Pattern

Question 6

PHarm treatment for PAget

Answer 6

Aminophosphonates

Reduce bone turnover