Chapter 4 question Flashcards
As a consequence of repeated use of a drug, larger and larger doses of the drug may be necessary in order to achieve the same effect. This is a consequence of the development of
tolerance
The calming effect of alcohol on neurons is probably mediated by _______, which is/are one of alcohol’s breakdown products.
allopregnanolone
ACh is the main transmitter used at mammalian….
neuromuscular junctions
The anxiolytic drug Valium belongs to the class of drugs known as….
benzodiazepines
Alcohol’s calming influence may be attributable to its ability to _______ secretion
increase allopregnalone
A drug that affects the function of a receptor without impeding the access of neurotransmitter molecules to their binding sites on the receptor is a…
noncompetitive ligand
If a newly developed drug is found to bind to serotonin receptors and activate them, the drug is classified as…
an agonist
What drug is a serotonergic agonist and functions like an anxiolytic?
Buspar
Which opiate receptors are involved in the reinforcing effects of opiates?
μ
Down-regulation is the process by which…..
an excessive number of transmitter molecules are available to the receptor over a period of time, causing a decrease in the receptor sites that can be counted.
Drugs that are effective in reducing the symptoms of schizophrenia are known as
neuroleptics
Both PCP and ketamine act by _______ receptors.
blocking NMDA
A major site of origin of projections using the neurotransmitter dopamine is the…
substantia nigra
The development of _______ tolerance may result in a change in the number of receptors present in the cell membrane.
functional
The dose at which a drug has a half-maximal response is termed the…
ED-50
