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Flashcards in 5a] Immunologic Deck (36)
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1

Protection against infectious organisms

Immune system

2

Two types of immunity

Humoral and cell-mediated

3

4 ways to classify immuno dysfunctions

1- immunodeficiency
2- hypersensitivity
3- autoimmune
4- immunoproliferative

4

Inflammation of disarthrodial joints

RA

5

3 stages that RA progresses in

1- synovium swelling
2- rheumatoid nodules develop
3- erosion of bone, cartilage-enzyme release

6

Hallmark sign of RA in radiograph

Articular erosion

7

Who is RA most common in ?

Women 20-40

8

Risk factors for RA

Genetic susceptibility (HLA-DR4)
Hormones in women
Trigger: infection, environment, stress

9

Signs and Sx of RA

Constitutional Sx
Joint pain, swell, warm, red, stiff
Morning stiffness
+ RA factor

10

What joints are affected in RA

MTP
MCP
PIP
Wrist and knees

11

Joint pain in RA is usually,,,

Bilateral

12

Dx of RA- ACR criteria - how many must be present?

4 out of 7

13

ACR criteria for Dx of RA

1- morning stiff more than an hour
2- soft tissue swell in hands
3- soft tissue swell in 3 out of 14 joint groups
4- symmetrical swelling in 1 joint area
5- rheumatoid nodule
6- + RA factor
7- radiograph changes in hands or wrist

14

Subchondral cyst formation

RA and OA

15

Joint space narrowing

RA and OA

16

Bony erosion at joint margins - hallmark sign

RA

17

Osteophytosis- hallmark sign

OA

18

Periarticular osteopenia

RA

19

Subchondral sclerosis

RA

20

Joint sublux

RA

21

Ankylosis

RA

22

Example of immunodeficiency

AIDS

23

Examples of hypersensitivity

Allergies to drugs
Contact dermatitis
Transplant rejection

24

5 examples of autoimmune

Fibromyalgia
RA
SLE
Polymyalgia rheumatica
Spondyloarthropathies (Guilin-Barre)

25

Example of immunoproliferative

Leukemia

26

Tenderness in fibromyalgia

Pain with light touch

27

Widespread- lasting more than 3 months

Fibromyalgia

28

Localized pain

Myofascial pain

29

Tender points = “pain” is + response

Fibromyalgia

30

Trigger points- hallmark

Myofascial pain