6. Complement proteins

Question 1

Non specific humoral factors that consist of complex series of more than 30 soluble and cell bound proteins

Answer 1

Complement proteins

Question 2

What is the main function of complement proteins?

Answer 2

Eliminates or destroy cells that triggers complement activation

Question 3

Who coined complement?

Answer 3

Paul Ehrlich

Question 4

Who elucidated the function of complement proteins?

Answer 4

Jules bordet

Question 5

What are the major fraction for complement protein?

Answer 5

Beta 1 and beta 2 globulin

Question 6

How complement proteins eliminated cells?

Answer 6

Lysis

Question 7

How many major complement proteins?

Answer 7

9 (C1 - C9)

Question 8

What is the sequence for the Classical pathway?

Answer 8

C1, C4, C2, C3, C5, C6, C7, C8, C9

Question 9

How is peptide chain being assigned with what language?

Answer 9

Greek Letter (Gamma greek sign)

Question 10

How is peptide chain being assigned with what language?

Answer 10

Greek Letter (Gamma greek sign)

C3:
C3 alpha
C3 Beta
C3 Gamma

Question 11

Activated complement proteins are assigned in _________ letters

Answer 11

Lower case

Ex:
C3a
C3b

Question 12

What is the end result for classical pathway?

Answer 12

Lysis of foreign cells

Question 13

What are the 3 recognition unit for classical pathway?

Answer 13

C1q
C1r
C1s

(Tri molecular complex)

Question 14

Largest C protein which initiates C activation by binding to 2 adjacent Fc portion of an antigen-bound IgM or IgG

Like a Docking site

Answer 14

C1q

Question 15

Activation Relys on in the presence of immune complex (IgM or IgG)

Answer 15

Immune complex dependent

Question 16

What immunoglobulin is the best complement activator?

Answer 16

IgM

because of pentameric

IgG on the otherhand need 2 to have 2 Fc

Question 17

Recognition unit for proteolytic zymogen

Answer 17

C1r

Question 18

Recognition unit that is a

zymogen when free,
esterase when bound

Responsible for cleaving or activating the next complement protein

Answer 18

C1s

Question 19

Tri molecular complex is held together by?

Answer 19

Calcium ions

Ca2+

Question 20

Activation units what is the 1st activation

Answer 20

C4

Question 21

Function of C4?

Answer 21

Activates C1s to cleaves C4alpha

Question 22

What is the resulting fragments?

Answer 22

C4a and C4b

Question 23

What is C4a?

This triggers inflammatory cells causing degranulation such as histamine

Answer 23

anaphylatoxin

Question 24

what is C4b?

Answer 24

Attaches to cell membrane

(of foreign cells)

Question 25

NOTE: C4 composed 3 peptides (Alpha, Beta, Gamma)

Question 26

What is the 2nd activation unit? This binds to C4b and is cleaved

Answer 26

C2

Question 27

C2 is activated by?

Answer 27

C1s

Question 28

What is the resulting fragments for C2?

Answer 28

C2a, and C2b

Question 29

remains w/ C4b w/c forms ____________ or ___________

Answer 29

C4b2a or C3 convertase

Question 30

C3 convertase was made in the presence of?

Answer 30

Magnesium

Question 31

Most abundant complement protein in serum which serves as the merging point of the activation pathway which lead to common pathway? Secreted by macrophages

Answer 31

C3

Question 32

C3 is cleaved by?

Answer 32

C3 convertase

Question 33

What are the resulting fragments of C3?

Answer 33

C3a and C3b

Question 34

What is the function C3a?

Answer 34

anaphylatoxin

Question 35

What is the function of C3b?

Answer 35

Binds to C42a to form C4b2a3b (C5 convertase)

Question 36

Can act to opsonins independently?

Answer 36

C3b

Question 37

1st membrane attack unit?

Answer 37

C5

Question 38

What are the resulting fragment for C5?

Answer 38

C5a and C5b

Question 39

Resulting fragments of C5 that serves as a chemoattractant or chemotactic factor and anaphylatoxin

Answer 39

C5a

Question 40

Attracts the migration of phagocytes

Answer 40

Chemotactic factor

Question 41

Resulting in fragments of C5 that attaches to cell surface Docks for membrane attack units (Susunod an proteins)

Answer 41

C5b

Question 42

2nd and the 3rd membrane attack unit respectively

Answer 42

C6 and C7

Question 43

Attaches to C5b to form the first membrane attack complex which is?

Answer 43

C5b67

Question 44

Inserted to the cell membrane creating pores or erosions

Answer 44

C8 and C9

Question 45

When C8 attaches to C5b67?

Answer 45

slow lysis

Question 46

What happen when C9 attaches?

Answer 46

C5b6789 = fast lysis