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Psychobiology > 6- Neurotransmission: Drug Abuse > Flashcards

6- Neurotransmission: Drug Abuse Flashcards

1
Q

Nicotine interacts with which receptor

A

Acetylcholine receptor

Nicotine receptor

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2
Q

Alcohol modulates which receptor

A

GABA-A
GABA-B
NA receptor
Opioid receptor

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3
Q

Opiates interact with which receptor

A

Opioid receptor

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4
Q

MDMA interacts with which receptor

A

Serotonin 2A receptor

Serotonin transporter

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5
Q

Cocaine interacts with which receptor

A

Dopamine transporter

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6
Q

Amphetamine interacts with which receptor

A

Releases dopamine

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7
Q

Barbiturates interacts with which receptor

A

Modulates GABA-A receptor

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8
Q

Cannabis interacts with which receptor

A

Cannabinoid CB1 receptor

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9
Q

Effects of cocaine

A

Blocks dopamine transporter- increases levels of dopamine

Local anaesthetic- resembles lidocaine

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10
Q

Effects of amphetamine

A

Enhances dopamine release and reduces reuptake

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11
Q

How is dopamine released

A

Presynaptic depolarisation

It is then taken back up by the dopamine transporter (DAT)

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12
Q

What does DAT do

A

Takes dopamine from the post synapse and is transported to the VMAT which reincorporates it into vesicles

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13
Q

What is DAT

A

Dopamine transporter

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14
Q

What is VMAT

A

Vesicular monoamine transporter

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15
Q

How does cocaine affect the DAT

A

Blocks the DAT

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16
Q

How does amphetamine affect dopamine

A

Amphetamine is transported into the presynaptic terminal by DAT
It then displaces dopamine from vesicles so it’s released from the synapse

17
Q

Where is the CB1 receptor expressed

A

Mostly CNS

18
Q

Where is the CB2 receptor expressed

A

Mostly peripheral

19
Q

What is THC’s affinity and efficacy

A

High affinity
Lower efficacy
Partial agonist

20
Q

Full agonist

A

Produces maximal stimulation of the target at higher doses- high efficacy

21
Q

Partial agonist

A

Produces a smaller effect than a full agonist even at higher doses
Can compete with a full agonist, reducing its effect
Moderate efficacy

22
Q

Antagonist

A

Produces a negligible effect regardless of dose
Low efficacy
Reduces the effect of partial and full agonist by competition at the receptor

23
Q

Treating drug addiction

A

Substitute the drug with one with less rewarding properties

Block the effects of a rewarding drug by treating with an agonist or partial agonist

Psychobiology (21 decks)

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