7.5 Agents of Viral Gastrointestinal Infections

Question 1

Most common cause of viral disease

Answer 1

Rotavirus

Question 2

Rotavirus group that is primary human pathogens

Answer 2

Group A

Question 3

2 concentric capsid shells with icosahedral symmetry

Non-enveloped, double shelled

Answer 3

Rotavirus

Question 4

Rotavirus is inactivated by

Answer 4

95% enthanol, phenol, chloride and boiling water

Question 5

Antigenic properties used to identify rotavirus

Answer 5

Inner unit: VP6

Outer unit: VP4 (P serotype) and VP7 (G serotype)

Question 6

Released by rotavirus that induces electrolyte imbalance by triggering a signal transduction pathway

Answer 6

NSP4 enterotoxin

Question 7

Rotavirus replication in the ____ followed by acute onset of vomiting and diarrhea

Answer 7

Small intestine

Question 8

Common source of infection in adults is ____

Answer 8

Contact with pediatric cases

Question 9

Rotavirus epidemiology: most common cause of _____ in _____; prominent during the ____; inactivated by ____

Answer 9

Gastroenteritis
Children
Winter season
Alcohol

Question 10

Oral rhesus vaccine is withdrawn a year later because of reports of ____

Answer 10

Intussusception

Question 11

Norwalk virus family

Answer 11

Caliciviridae (4 genera - Sapovirus, Lagovirus, Vesivirus, Novovirus)

Question 12

Cup-like depressions on the surface of the virus with icosahedral symmetery; single-stranded RNA and contain single structural protein

Answer 12

Norwalk virus

Question 13

Norwalk virus is maintained in iced and partially cooked ____., eliminated by ____

Answer 13

Oysters

Chloride-based disinfectants

Question 14

Most important cause of epidemic viral gastroenteritis

Answer 14

Norwalk virus

Question 15

Rapid onset of diarrhea, N/V, low-grade fever, abdominal cramps, headache, and malaise

Answer 15

Norwalk virus gastroenteritis

Question 16

Most widely used technique for detection of human caliciviruses in clinical specimens

Answer 16

RT-PCR