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Microbiology > 7.20 Agents of Viral Hepatitis > Flashcards

7.20 Agents of Viral Hepatitis Flashcards

1
Q

Infectious hepatitis

A

HAV

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2
Q

Serum hepatitis

A

HBV

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3
Q

Post-transfusion hepatitis

A

HCV

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4
Q

Enterically transmitted hepatitis

A

HEV

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5
Q

Picornaviridae
Icosahedral
ssRNA
Fecal oral

A

HAV

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6
Q

Autoclaving

A

HAV

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7
Q

Principal age distribution

A

Children

Young adults

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8
Q

Abrupt onset
Elevated IgM
No complication
Confers immunity

A

HAV

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9
Q

Detectable at onset of symptoms

Lifetime persistence

A

Anti-HAV

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10
Q

Indicates recent infection with HAV

4-6 months after infection

A

IgM anti-HAV

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11
Q

Gold standard for diagnosing hepatitis

A

HAV IgM

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12
Q

Highest rate of HAV incidence is between:

A

5-14

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13
Q

HAV immunity

A

2 doses

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14
Q 
Hepadnaviridae
Spherical
dsDNA circular
Acid-sensitive
Chronic disease
Oncogenic
A

HBV

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15
Q

Made up exclusively of HBsAg

A

Spherical

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16
Q

Less frequently observed

A

Dane particles

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17
Q

Made up exclusively of HBsAg

A

Tubular or filamentous

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18
Q

Four phenotypes of HBsAg

A

adw (predominant), ayw, adr, ayr

19
Q

Template for production of HBV mRNAs and RNA pre-genome

A

ccDNA

20
Q

Predominant route of HBV infection

A

Parenteral

21
Q

More extensive damage which prevents orderly liver cell regeneration

A

Acute viral hepatitis

22
Q

Mild benign disease that may follow acute HBV infection

A

Persistent unresolved viral hepatitis

23
Q

Histologic changes include inflammation and necrosis to collapse of the normal reticulum framework with bridging between portal triads or terminal hepatic veins

A

Chronic active hepatitis

24
Q

Most useful detection methods for HB

A

ELISA for HBV Ag and Ab

PCR viral DNA

25
Q

Occur early in the incubation period

A

DNA pol, HBV DNA, HBeAg

26
Q

Associated with recovery from infection

Persists for more than 6 months in the presence of HBeAg

A

HBsAg

27
Q

Detected at the onset of clinical illness

Indicative of viral replication

A

IgM-specific anti-HBc

28
Q

Adults infected with HBV are at high risk of developing ____

A

HCC

29
Q

First line therapies for HBV

A

Pegylated IFN alfa-2a
Entecavir
Tenofovir

30
Q

Guanosine analogue inhibitor of HBV polymerase

A

Entecavir

31
Q

Nucleotide analogue inhibitor of HBV reverse transcriptase and polymerase

A

Tenofovir

32
Q

Second line therapies for HBV

A

Telbivudine

33
Q

Cytosine nucleoside analogue

Inh of HBV DNA pol

A

Telbivudine

34
Q

Third line therpay for HBV

A

Lamivudine

Adenofovir

35
Q

Nucleoside analog viral polymerase inhibitors

A

Lamivudine

Adenofovir

36
Q 
Flaviviridae
Spherical
(+) stranded ssRNA
Chronic disease
Oncogenic
A

HCV

37
Q

HCV treatment

A

Pegylated IFN + ribavirin

38
Q

First generation protease inhibitor drugs

Target the viral protease, which cleaves the translated viral polypeptide into functional proteins

A

Telaprevir

Boceprevir

39
Q

Second generation HCV antivirals

A

Sofosbuvir

Simepravir

40
Q

Nucleotide analog HCV viral RNA inhibitor

A

Sofosbuvir

41
Q

HCV protease inhibitor

A

Simepravir

42
Q 
Unclassified
Envelope- HBsAg
ssRNA, negative sense, circular
Parenteral
Smalles known human antigen
Not sexually transmitted
A

HDV

43
Q

Only protein encoded for by HDV RNA

A

HDAg

44
Q 
Hepeviridae
ssRNA, positive sense
Not enveloped
Fecal-oral
Fulminant disease in pregnancy
A

HEV

Microbiology (4 decks)

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