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Basic science > Bone formation > Flashcards

Bone formation Flashcards

1
Q

Actions of PTH

A

Activate osteoclasts
Converts 1 OH Vit D -> 2 OH in KIDNEYS
Increased CA resorption
Increased PHOS excretion

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2
Q

Preferred lab test for Vit D level

A

25-OH cholecalciferol

1st OH added in LIVER

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3
Q

Proximal to distal growth in embryo

A

Apical ectodermal ridge (FGF)

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4
Q

Anterior-posterior growth in embryo

A

Zone of depolarizing activity (Sonic hedgehog, HOX)

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5
Q

what the notochord becomes

A

anterior VB

Nucleus pulposus

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6
Q

Compression at growth plate

A

SLOWS longitudinal growth

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7
Q

Tension at growth plate

A

ACCELERATES longitudinal growth

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8
Q

Proliferative zone physeal diseases

A

Achondroplasia
Gigantism
MHE

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9
Q

Hypertrophic zone physeal diseases

A

SCFE
Rickets (prov calcification)
Salter Harris fx (prov calcification)

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10
Q

where osteochondromas come from

A

Groove of Ranvier

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11
Q

Fastest bone graft resorption

A

CA sulfate

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12
Q

Highest compressive strength bone graft

A

CA phosphate

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13
Q

What does Sonic hedgehog do

A

A->P limb development via ZPA

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14
Q

What does Indian hedgehog do

A

osteoclast precursors

Upstream from Wnt

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15
Q

Longitudinal growth at the physis (what zone)

A

Proliferative zone (chondrocyte hypertrophy)

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16
Q

Provides chondroctyes to joint surface

A

Resting zone

17
Q

Calcification of the matrix within the physis

A

Hypertrophic zone

18
Q

Tension at growth plate causes what

A

Accelerated longitudinal growth

19
Q

BMP cell signaling

A

SMADs

Basic science (7 decks)

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