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BMS3031 Molecular Mechanisms of Disease > Kidney Regeneration > Flashcards

Kidney Regeneration Flashcards

1
Q

What percentage of podocyte loss characterises fibrosis?

A

20-40%

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2
Q

What percentage of podocyte loss characterises global sclerosis?

A

> 60%

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3
Q

List four possible uses of iPSC?

A

Disease modelling, toxicology screening, individual response to intervention, cell replacement therapy.

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4
Q

What is the potency of mesenchymal stem cells?

A

Multi-potent

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5
Q

How do mesenchymal stem cells reduce inflammation?

A

Interfere with dendritic cells and T cells, arrest B cell maturation and . proliferation, alter macrophage phenotype towards repair-type.

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6
Q

Why can mesenchymal stem cells be used for molecule delivery?

A

Mesenchymal stem cells have many exosomes. The cells or the exosomes can be used for delivery.

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BMS3031 Molecular Mechanisms of Disease (21 decks)

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