6.2 Adrenergic Meds Flashcards

Question

What is fenoldopam used for? Receptor?

Answer 1

D1 agonist  peripheral vasodilation | Treatment of severe HTN (ICU med)

Answer 2

Displace storage- Drug comes in, displaces neurotransmitter from vesicles that store them, so when signal for release comes, cause excessive release Inhibit reuptake MAO Inhibiter COMT inhibitor

Answer 3

“amphetamine-like” = “displacers” | Ex: Amphetamine, methamphetamine, phendimetrazine (bontril), and methylphenidate

Answer 4

NE transport inhibitor Ex: Atomoxitine (Strattera) – ADHD – selective for NE reuptake transporter Sibutramine (Meridia) – weight loss – serotonin and NE reuptake inhibitor Duloxetine – chronic pain, fibromyalgia – SNRI Cocaine – local anesthetic – dopamine reuptake inhibitor at the “pleasure centers” in the brain – highly abuse

Answer 5

Treatment of Acute hypotension or shock (i.e. maintaining BP) Ex: Levophed (norepinephrine); Neo-synephrine (phenylephrine) Chronic orthostatic hypotension Hypertension – Centrally acting alpha-2 agents Inducing local vasoconstriction – decongestant Bronchial dilation Anaphylaxis Mydriatic agent (i.e. phenylephrine) Tocolytics – suppress premature labor Weight loss Narcolepsy – i.e. amphetamine, methamphetamine ADHD

Answer 6

When alpha receptors stimulated, cause vasoconstriction, so when blocked, cause vasodilation in arterioles and vains = lower BP and vascular resistance (afterload) If BP too low with these meds, body will attemot to compensate, up HR, …. Keeps building until pt crashes SA- reflex tachycardia- autonomic reflex kicks in, hr increases Orthostatic HTN- causes peripheral vasculature to be less responsive to vasoconsteiction Decreases resistance to flow of urine… promotes urinary outflow

Answer 7

Blockade of alpha1 receptors in arterioles and veins No reflex tachycardia d/t alpha 1 selective Good PO absorption – 70% bioavailability 95% protein bound; T1/2 = ~3hrs

Answer 8

Less potent than prazosin High specificity for alpha-1 receptors >90% bioavailability; T1/2 = 12hrs Tx: HTN, BPH

Answer 9

A1 blocker

Answer 10

Competitive alpha-2 blocker Found in bark of Pausinytalia yohimbe and Rauwolfia root Structure resemble reserpine Enters CNS incr BP and HR (opposite to clonidine) Also blocks 5HT Tx: male sexual dysfunction – less conclusive than PDE5 inhibitors

Answer 11

covalent bond to receptor irreversible blockade | Treatment of pheochromocytoma (adrenal tumor secrete lots of catecholamines)

Answer 12

A2 blocker Indications: Pheochromocytoma Extravasation necrosis from alpha agonists HTN crises follow abrupt w/d of clonidine Caution: in PUD enhance GI secretion d/t histamine release SE: Hypotension Tachycardia Arrhythmias MI

Answer 13

Lower BP Increase airway resistance Reduce intraocular pressure Selectivity is dose-dependent

Answer 14

-olol | BBEAAM - We'll have a list of drugs

Answer 15

Acebulol- B1 blocker and partial agonist– When binds to receptor, blocks the receptor, but stiumulates it a little= won’t lower BP as much Esmolol- T1/2 10min!! Use if need a short acting B1 antagonist

Answer 16

Used off-label for panic attacks, anxiety; anti-arrythmic; migraine prophylaxis; hyperthyroid

Answer 17

partial agonist and A1 selective

Answer 18

``` Bradycardia Mild sedation Cold hands Vivid dreams Depression – rare Nonselective agents – worsen preexisting asthma Depressed myocardial contractility and excitability Cautious in decompensated HF ```

Answer 19

With asthma- B2 blockers cause broncho constriction asthma exascerbation Can case/worsen heart failure if used in decompensated HF

6.2 Adrenergic Meds Flashcards

(43 cards)