Block 1 - Connective Tissue Flashcards
Does CT contain a lot of cells?
No, it contains a lot of extracellular matrix
What are the 4 main functions of connective tissue?
Structural framework
Storage of metabolites
Defense and protection
Repair of other tissues (fibrous scar)
What does the extracellular matrix consist of?
Fibers and ground substance
What are three types of fibers found in CT?
Collagen fibers, reticular fibers, elastic fibers
What comprises collagen fibers and reticular fibers? And elastic fibers?
Collagen 1 and 2 - collagen fibers
Collagen type 3 - reticular fibers
Elastin and Fibrillin - elastic fibers
What cells are polymerized to form collagen and reticular fibers?
Collagen fibrils
What is the only type of collagen that can form bundles?
Collagen type 1
What are the 4 types of collagen? Where are each found?
Type 1 - dermis, skin, fascia, bone (proper CT)
Type 2 - cartilage
Type 3 - reticular fibers (supportive network for cells)
Type 4 - basal lamina
What disease is characterized by defective collagen fibers resulting in skin hyperelasticity and losse unstable joints?
Ehler-Danlos Syndrome
What two fibrillar proteins are elastic fibers made out of?
Elastin and Fibrillin
What is mutated with Marfan’s Syndrome? What symptoms are associated?
Fibrillin gene. Cardiovascular, skeletal,a nd ocular defects (mitral valve prolapse)
What are the three major components of ground substance?
Proteoglycans
Glucosaminoglycans
Multiadhesive glycoproteins
What glucosaminoglycan is always present in the ECM?
Hyaluronic acid
What is the structure of proteoglycans?
GAGs covalently attached to a protein core
What is the role of multiadhesive glycoproteins? what are two types?
Cross-link collagen, ECM, and cells. Stabilizes ECM.
Fibronectin and Laminin
