Anti-parkinson's

Question 1

Levodopa

Answer 1

CLASSIFICATION =
Antiparkinsons

USE =
Parkinsons disease

MODE OF ACTION :
Crosses the blood brain barrier and is converted into dopamine

ADVERSE =
Dose dependent - nausea, vomiting, diarrhoea , hypertension , anxiety , aggression, paranoia.

Question 2

Sinemet (levodopa + carbidopa)

Answer 2

CLASSIFICATION =
Antiparkinsons

USE =
Parkinsons disease

MODE OF ACTION :
Carbidopa (an enzyme inhibitor) slows down peripheral metabolism to allow more levodopa to cross the blood brain barrier and convert to dopamine.

ADVERSE =
Dose dependent - nausea, vomiting, diarrhoea , hypertension , anxiety , aggression, paranoia.

Question 3

Entacapone ,

Tolcapone

Answer 3

CLASSIFICATION =
Antiparkinsons

USE =
Parkinsons disease

MODE OF ACTION :
Inhibits the COMT synaptic enzyme which metabolises neurotransmitters. Used with combination therapy (As does not cross the blood brain barrier).

ADVERSE =
Dose dependent - nausea, vomiting, diarrhoea , hypertension , anxiety , aggression, paranoia.

Question 4

Benzotopine

Answer 4

CLASSIFICATION =
Antiparkinsons

USE =
Parkinsons disease

MODE OF ACTION :
Blocks cholinergic receptors to stop acetylcholine (neurotransmitter) from binding

ADVERSE =
Dry mouth , blurred vision , constipation