Antidepressants

Question 1

Fluoxetine
Citalopram
Sertraline

Answer 1

CLASSIFICATION =
Antidepressant
Selective Serotonin Re-uptake Inhibitor (SSRI)

USE=
Depression

MODE OF ACTION=
This selectively inhibits the re-uptake of serotonin at the presynaptic neuron , this then increases the amount of serotonin in the brain ,

ADVERSE =
Nausea, nervousness, insomnia, sexual dysfunction

Question 2

Amitriptyline ,
Doxepin ,
Dothiepin

Answer 2

CLASSIFICATION =
Antidepressant 
Antihistamininic 
Anticholinergic 
Antiadrenergic 

USE=
Depression

MODE OF ACTION=
Non -selectively blocks re-uptake of neurotransmitters, resulting in high levels of noradrenaline and serotonin in the brain

ADVERSE =
Dry mouth , sedation , weight gain , postural hypotension

Question 3

Moclobemide

Answer 3

CLASSIFICATION =
Antidepressant
Reversible monoamine oxidase inhibitor (RIMA)

USE=
Depression

MODE OF ACTION=
Selectively inhibits the enzyme monoamine oxidase -A to stop break down of noradrenaline

ADVERSE =
Sleep problems , agitation , dizzy , tremor

Question 4

Phenylzine

Answer 4

CLASSIFICATION =
Antidepressant
Monoamine Oxidase Inhibitor ( MOAI)
Adrenergic agonist

USE=
Depression

MODE OF ACTION=
Inhibits the enzyme monamine oxidase -A and -B to stop the break down of noradrenaline , Also causes adrenergic stimulation of the SNS.

ADVERSE =
Increased HR and BP , dry mouth , nausea, constipation , drowsiness