Aplastic anemia Flashcards
Most common cause of Aplastic anemia
ideopathic
bone marrow failure is caused by suppression or injury to the stem cells, this result in______.
no RBCs being produced
bone marrow fails to produce mature RBCs, this results in ____.
pancytopenia
possible causes of Aplastic anemia
autoimmune, congenital, chemo and radiation, toxins, drugs, post viral hepatitis, pregnancy
symptoms of Aplastic anemia
o Weakness and fatigue (due to anemia)
o Bacterial or fungal infections (due to neutropenia)
o Mucosal or skin bleeding (due to thrombocytopenia)
physical exam findings of Aplastic anemia
o Pallor, petechiae, purpura
o Hepatosplenomegaly, lymphadenopathy, and bone pain should NOT be present
diagnostic labs for aplastic anemia
Panocytopenia
reticulocytopenia
bone marrow biopsy will appear hypo cellular- GOLD STANDARD
treatment for aplastic anemia
Mild cases-supportive care:
- Erythropoietic or myeloid growth factors
- RBC/platelet transfusions
Bone marrow transplant
