antiphospholipid syndrome

Question 1

how does antiphospholipid syndrome manifest?

Answer 1

recurrent venous or arterial thrombosis and or fetal loss

Question 2

hallmark for antiphospholipid syndrome

Answer 2

anticardolipin Ab’s and lupus anticoagulant

Question 3

what diseases is secondary antiphospholipid syndrome associated with

Answer 3

autoimmune disorders, cancer, infections (malaria, syphillis), drugs, genetics

Question 4

percentage of population with antiphospholipid syndrome antibodies

Answer 4

1-5 %

Question 5

pathophysiology of antiphospholipid syndrome

Answer 5

antiphospholipid syndrome antibodies to the phospholipids block attachment of binding protein which results in being predisposed to thrombosis

Question 6

labs for antiphospholipid syndrome

Answer 6

lupus anticoagulants- increased aPTT, presence of APL antibodies

Question 7

side effects of antiphospholipid syndrome

Answer 7

permanently disability or death at a young age

complications: CVA,Pulmonary hypertension, renal failure, MI,