Parkinson's Disease

Question 1

Name 10 drugs that can be used in the treatment of Parkinson’s Disease.

Answer 1

1. levo-dopa
2. carbidopa
3. tolcapone
4. entacapone
5. amantadine
6. selegiline
7. ropinirole
8. pramipexole
9. tryhexyphenidyl
10. benztropine

Question 2

What are the non-motor manifestations of Parkinson’s Disease?

Answer 2

• cognitive dysfunction
• mood disturbances
• sleep disorders
• autonomic dysfunction

Question 3

Levodopa is…………..of dopamine

Answer 3

The immediate metabolic precursor of dopamine

Levodopa crosses BBB, once it’s crossed it is decarboxylated to dopamine

Question 4

How does dopamine work, once inside the CNS?

Answer 4

Once inside brain, dopa is able to access D2 receptors in the nigrostriatum and enhance dopaminergic transmission

Question 5

Levo-dopa/ Dopamine therapy is contraindicated in ..?

…seen as how it increases increases dopamine levels in CNS 🙄(hint hint)

Answer 5

In patients with psychosis !!

Remember antipsychotics are all about blocking that dopamine receptor

Question 6

Name the peripheral dopa-decarboxylase inhibitor.

Answer 6

Carbidopa ( 🚔)

Question 7

Name the COMT inhibitor.

COMT converts levodopa to 3 O methyldopa in periphery

Answer 7

Entacapone- entrance

Tolcapone- Tall al Capone (also acts in CNS) causes hepatic failureeeee so entacapone is preferred

Question 8

What other drug increases dopamine level in CNS?

Answer 8

Selegiline (selective MAO-B inhibitor)