Osteoporosis

Question 1

Name four bisphosphonate drug names.

Answer 1

Alendronate, Risendronate, Ibandronate,Zolendronate

ZIRA

Question 2

Denosumab

Answer 2

= human monoclonal antibody that binds to and prevents the action of RANKL.

Denosumab inhibits osteoclasts formation and activity

• at least as effective as potent bisphosphonates in inhibiting bone respiration and can be used for tx of post-menopausal osteoporosis.
• administered sc every 6 mo (avoids GI SE)
• increased risk of infection