parkinson's disease

Question 1

I-Dopa

Answer 1

dopamine precursor that is converted to dopamine

Question 2

selegiline/deprenyl

rasalagine

Answer 2

inhibits the metabolism of dopamine by MAO-B
(MAO-A is in the CNS while MAO-B is in the periphery)
rasalagine is newer and more powerful

Question 3

entacopone

Answer 3

inhibits the metabolism of dopamine and I-DOPA by COMT

Salevo combines Idopa plus carbidopa plus entacapone

Question 4

Bromocryptine
pramipexole
ropinirole

Answer 4

stimulate post-synaptic dopamine receptors

bromo is an ergot derivative

Question 5

amantadine

Answer 5

stimulate the release of dopamine from nerve endings and may also inhibit reuptake

Question 6

benztropine
triheriphenidyl
diphenhydramine

Answer 6

centrally acting anti-muscarinics that reduce cholinergic activity
diphenhydramine is an antihistiamine

Question 7

I dopa with carbidopa = sinemet

Answer 7

carbidopa does not enter the brain, so it reduces the metabolism of DOPA to dopamine in the periphery. this allows the reduction in the dose of I-DOPA by about 75% and greatly decreases the severity of some perhpheral side effects
Idopa causes nausea

Question 8

cardio SE of Idopa

Answer 8

postural hypotension, tachycardia, arrhythmias, although the frequency and severity of the effects can be decreased significantly by the concurrent use of carbidopa, one must exercise extreme caution in using I-DOPA in pts with existing cardiovascular disease

Question 9

preferred drug to block psych issues with IDOPA

Answer 9

clozapine

but have to monitor blood