Exam 3: Developmental Anomalies Flashcards
Defectss in growth or development of an organ or tissue
Developmental anomalies
T/F. Developmental anomalies are present at birth?
T. just not obvious
What are the two manifestations of developmental anomalies
- Anatomic Malformations
2. Biochemical defects
What are some examples of Anatomic malformations
- Failure to fuse
- Failure to separate
- Cysts
- Failure of structure to develop
- Abnormal development of structure
- Ectopic development
What are some examples of biochemical defects
- Inability to synthesise adequate amts. of enzyme or protein
Lysosomal storage dz
Albinism
Biochemical Defects are usually due to what?
Genetic mutation
Pathogenesis of Anatomical Developmental anomalies occur due to ___________.
The injury of cells during embryogenesis
T/F. All anatomical developmental anomalies are in utero
T
The nature of the anatomical defect that results depends on what 2 things?
- Timing
2. Tissue injured
What happens if you have damage to the embryo?
Death and resorption
What happens if you have damage to early foetus?
Developmental anomaly
What happens if you have damage during last trimester?
Abortion, stilbirth, weak neonate
What happens if you have damage to the zygote during development?
Death and resorption
What happens if you have damage to the embryo during organogenesis?
- Developmental anomaly
2. Embryonic death and abortion
What happens if you have damage to the growing fetud?
Death, abortion, mummification, stillbirth, weak neonates
