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Question 1

Site of multiplication of measles

Answer 1

Resp. epithelium & Lymph nodes

Question 2

Spread of measles from rep site via

Answer 2

Monocytes

Question 3

Stages of Measles Infections

Answer 3

Prodome, Rash, Resolution

Question 4

Characteristics of Prodrome of Mealses

Answer 4

1-12 days post inf.
Fever
3 c’s
Koplik Spot’s

Question 5

Characteristics of Rash of Measles

Answer 5

Extensive rash developing 3-4 days following start of prodrome. Ears to forehead to face to neck to chest/trunk to extremities

Question 6

Characteristics of Resolution of Measles

Answer 6

Viremia ceases and inc. in AB titers. Rash disappears in same order appeared.

Question 7

Causative agent of Measles

Answer 7

Paramyxovirus
-ssRNA (own RNA pol)
Enveloped
-F protein (spread inf.)
-H protein (hemagg. for attach)

Question 8

Measles Complications (4)

Answer 8

Pneumonia
CNS involv.
Immunologic Suppression
Diarrhea

Question 9

Measles comp. of Pneumonia

Answer 9

Most measles deaths

aged/malnurished at risk

Question 10

Measles comp. of CNS involv

Answer 10

Acute encephalitis (common)
Subacute Schlerosing Panencephalitis
-FATAL, rare, slow prog.

Question 11

Measles comp. of Immunologic Suppression

Answer 11

Viral induced suppression leads to complicating secondary infections

Question 12

3 C’s of Prodrome of Measles

Answer 12

Cough
Conjunctivitis
Coryza

Question 13

Transmission of Measles

Answer 13

resp droplets

humidity and virion survival inv. related

Question 14

Communicability of Measles

Answer 14

Highly contag.
prodrome - 4/5 days post initial rash eruption
shedding prolonged in vit. A. def & immunocomp.

Question 15

Immunization from Measles infection

Answer 15

Life Long Immunity from nat. infection

Vaccine requires boosters

Question 16

Treatment of Measles

Answer 16

Symptomatic

Question 17

What inc. severity of measles infection?

Answer 17

Vit. A def.

Supplementation can dec. mortality up to 50%

Question 18

Measles Vaccine Info

-name, type, dosing, CI

Answer 18

MMR - live attenuated
1st dose: 12-15mo (must be before start school)
2nd dose: 4-6yo or >1mo after 1st
**2-5% of pop NOT protected from only first dose*
CI: preg, immunodef., egg sens.

Question 19

Measles outbreaks are from?

Answer 19

Non -vaccinated air travelers

Question 20

How is measles virus maintained?

Answer 20

Unbroken human transmission chain (human only virus and no “healthy” carriers)

Question 21

Measles prevention in people unable to get vaccine?

Answer 21

Immuniglobin

Question 22

Symptoms of Rubella

Answer 22

Maculopapular Rash

Mild fever, malaise, coryza, conjuctivits, lymphadenopathy

Question 23

Causative agent of Rubella

Answer 23

Togavirus

+ssRNA

Question 24

Route of transmission of Rubella

Answer 24

Resp. Droplets

Question 25

Communicability of Rubella

Answer 25

5 days prior to rash and 5 days post rash | -humans only resevoir

Question 26

Population commonly infected with Rubella

Answer 26

Older children, teens, young adults | NOT CHILDREN, opposite of measles

Question 27

Diagnosis of Rubella

Answer 27

Serology (AB detection) & Clinical

Question 28

TRX of Rubella

Answer 28

Symptomatic & Isolation for 7 days post rash

Question 29

Prevention of Rubella

Answer 29

MMR Vaccine -CI: Pregnancy 5-15% of children get fever, rash, lymphadenopathy 5-12 days post vaccine

Question 30

Complications of Rubella & describe (1)

Answer 30

Congenital Rubella Syndrome - maternal inf to fetus - Risk to fetus (earlier in preg, more sev. risk) - CRS patients can transmit disease up to 20mo

Question 31

Risk to fetus of CRS

Answer 31

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