Vitamins Flashcards
what is recommended vitamin A?
600-900ug/day
sources of vitamin A?
eggs, meat, dairy, leafy green vegetables
deficiencies and deficiency preventions for vitamin A?
night blindness and Bitot’s spots
ulceration
abnormal cell differentiation
dietary diversity and supplementation
breastfeeding infants
what form does vitamin A come in?
pro vitamin A (beta carotene)
non-pro vitamin A (lutein)
how does vision work?
photoisomerisation of 11-cod retinal to all-trans retinal
activation of protein (rhodopsin or iodopsin)
change in membrane potential of photoreceptor cell
transmitted as signal to optic nerve
other uses of vitamin A?
retinoic acid helps cellular differentiation
immunity - ‘anti-infection vitamin’
what is recommended vitamin D?
10ug/day
what are sources of vitamin d?
oily fish, eggs, red meat
fortified margarine and milk
sunlight activated
deficiencies and deficiency prevention for vitamin D?
rickets - reduced calcification of growing ends of bones leading to bow legs and knock knees
osteomalacia - reduced bone density
5-30 minutes midday exposure to sunlight at least twice a week
distance to the equator, time of day, season
issues with vitamin D?
can poison infants - high calcium leads to contraction of the blood vessels and high blood pressure
high sun exposure can cause skin cancer
forms of vitamin D?
D3 - UVB irradiation in the skin
D2 - irradiating ergosterol with UV light
what is recommended vitamin E?
20ug/day
sources of vitamin E?
corn, nuts, leafy vegetables
what is vitamin E used for?
anti-oxidant (prevents formation of free radicals)
modulates gene expression
what is recommended vitamin K intake?
65-80ug/day
sources of vitamin K?
K1 - leafy vegetables, green tea, cheese
K2 - synthesised by bacteria
uses of vitamin K?
synthesis of Gla
essential for coagulation
Gla permits binding of clotting proteins to lipid membranes
why do babies need vitamin K injections?
K is poorly transported across the placenta
human milk is low in K
injection is given to prevent hemorrhagic diseases
what is recommended vitamin B1?
1mg/day
sources of B1?
whole grains, meat, fish
deficiencies associated with B1?
wet beriberi - pyruvate and lactate accumulation, vasodilation
dry beriberi - nerves affected, loose sensation in the feet
loss of appetite and oedema
what is recommended vitamin B2?
1.3mg/day