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PHARM Final Self > 65 OTC > Flashcards

65 OTC Flashcards

(57 cards)

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1
Q

What are the 3 classification of drugs? And, what law/year came up with that?

A
  1. Prescription/legend-Durham Humphrey Amendments FDC act-1951
  2. OTC- Durham Humphrey
  3. Vitamins, minerals, and herbs- Dietary Supplement Health and Education- 1994
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2
Q

When is FDA involved for dietary supplements and herbals?

A

Only if safety concerns

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3
Q

What drug category falls under safe use w/minimal supervision?

A

OTC drugs

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4
Q

What category of drugs are regulated by FDA?

A

legend/ OTC

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5
Q

Does testing for efficacy for dietary/herbs exist? safety?

A
  1. No

2. left to the manufacturer

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6
Q

What drug category has ongoing testing efficacy and ongoing?

A

OTC Drugs

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7
Q

Give 3 reasons for why we should be familiar with OTC agents?

A
  1. Effective in treating common ailments
  2. May worsen existing conditions or interfere with prescriptions
  3. misuse/abuse may produce complications
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8
Q

What is a category I agent?

A

Useful and safe

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9
Q

What is a category 2 agent?

A

Unsafe or not useful

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10
Q

What is a category 3 agent?

A

unsure

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11
Q

What OTC category does brompheniramine and chlorpheniramine belong to?

A

H1 antihistamines- 1st gen-allergies

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12
Q

What OTC category does clemastine belong to?

A

H1 antihistamine-allergy- 1st gen

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13
Q

What OTC category does cetirizine and fexofenadine and loratadine belong to?

A

2nd Gen H1 antihistamine- allergy

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14
Q

What OTC category does dextromethorphan belong to?

A

antitussive- with codeine

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15
Q

What OTC category does oxymetazoline and xylometazoline belong to?

A

topical decongestants

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16
Q

What OTC category does guaifenesin belong to?

A

expectorants- reduce pulmonary mutants

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17
Q

What OTC category does benzoyl peroxide belong to?

A

acne vulgaris treatment

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18
Q

What OTC category does bismuth subsalicylate belong to?

A

miscellaneous antidiarrheal prepartions

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19
Q

What OTC category does polycarbophil, psyllium, and methyl cellulose?

A

bulk-forming laxative for constipation

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20
Q

What OTC category does Mg OH and polyethylene glycol belong to?

A

Osmotic laxative- for constipation

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21
Q

What OTC category does glycerin and bisacodyl belong to?

A

irritant laxative- for constipation

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22
Q

What OTC category does cyclizine and meclizine belong to?

A

antiemetics- prevent or treat motion sickness

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23
Q

What OTC category does diphenhydramine belong to?

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A

A few- sleep aid, anti emetics etc.

24
Q

What OTC category does doxylamine belong to?

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A

sleep aids- for insomnia

25
What OTC category does nicotine polacrilex belong to?
smoking cessation
26
What OTC category does naphazoline and tetrahydrozoline belong to?
ophthalmic vasoconstrictors- for bloodshot eyes
27
What OTC category does orlistat belong to?
weight loss- for obesity
28
What does it mean when a prescription only agent is now available as OTC?
demonstrated that it is safe for general use
29
What does the FDA keep systematically reviewing ?
OTC products for efficacy and safety- categories 1 and III-- remember II was already proven to be unsafe
30
What are the 3 hidden drugs found in analgesics?
antihistamines, caffeine, sympathomimetics
31
What is the hidden drug found in antitussives?
local anesthetics
32
What are the 3 hidden drugs found in cold/allergy medications?
alcohol, aspirin and sympathomimetics
33
What is the hidden drug in dermatologic OTC?
local anesthetics
34
What are the 2 hidden drugs in menstrual OTCs?
antihistamines and caffeine
35
What OTC classes have antihistamines as a hidden drug?
analgesics and mestrual
36
What OTC classes have local anesthetics as hidden drugs?
dermatologic and antitussives
37
What are the 5 guidelines for use of OTCs?
1. select simplest formulation 2. select therapeutically effective dose 3. product appropriate for symptoms 4. recommend generic product 5. be wary of gimmicks
38
What are 3 ways products are made different by (gimmicks)?
1. adding other ingredients that don't contribute 2. brand names selected to suggest specific uses or strength 3. special formulation- may or may not be helpful
39
What happens due to the fact that the public gets generally overwhelmed by differences?
Will use the one that is most heavily advertised
40
What are excipients?
inactive ingredients
41
T_F- excipients are only found in OTC and not prescription drugs?
False- both
42
Are excipients approved by FDA?
yes - 100s used
43
What might excipients affect?
dissolution and absorption of drug
44
T-F-- CaSO4 increased phenytoin levels and lactose decreased phenytoin levels?
False- other way around
45
What are the alka-seltzer plus cold & sinus tablets active ingredients? inactive ingredients?
1. aspirin, phenylephrine | 2. aspartame, docusate sodium
46
What are the active ingredients to sudafed?
pseudoephedrine
47
What are the active ingredients of advil PM?
ibuprofen, diphenhydramine
48
What is the active ingredient of afrin nasal spray?
oxymetazoline
49
Review avoidable cost to healthcare from Drug-drug interactions-
135 billion /year from ADRs 10-20% of those are from drug-drug
50
What drug-drug interactions prevent absorption?
1. chelation- cations/antibiotics 2. non-absorbable form- iron/H2 antagonist 3. non-specific binding- bile acid sequestrants
51
What are the 3 receptor interactions agonists and antagonists?
1. beta antagonist + beta2 agonist 2. methotrexate + folic acid 3. alpha1 +beta2 agonist
52
What is a common drug-drug interaction of catecholamines?
caffeine
53
What is a major drug-drug with antihistamines
alcohol
54
What is a major drug-drug with tetracyclines?
multivalent cations
55
What are 2 particularly dangerous interactions with warfarin?
NSAIDS and Macrolides
56
What are the 2 particularly dangerous interactions of ACE inhibitors?
K supplements, spironolactone
57
What is the most commonly overlooked interaction?
Inhibition of metabolic enzymes required for activation of prodrug

PHARM Final Self (3 decks)

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