Katzung Antibac checklist

Question 1

Describe the mechanism of antibacterial action of beta-lactam antibiotics.

Answer 1

Block tranpeptidase cross linking

Question 2

Describe 3 mechanisms underlying the resistance of bacteria to beta-lactam antibiotics.

Answer 2

1. formation of beta-lactamases
2. Structural change in target PBPs
3. changes in the porin structures

Question 3

List the major adverse effects of the penicillins and the cephalosporins.

Answer 3

Allergy and GI disturbances

Question 4

Identify the important features of aztreonam, imipenem, and meropenem.

Answer 4

active against P aeruginosas.

Question 5

Vancomycin MOA and Adverse effect

Answer 5

Gram-positive activity includes MRSA and PRSP strains

“Red-man” syndrome, rare nephrotoxicity

Question 6

Bind to 30S ribosomal tigecycline has broadest spectrum and resistance is less common

GI upsets, deposition in developing bones and teeth, photosensitivity, superinfection

Answer 6

Tetracyclines

Question 7

Bind to 50S ribosomal telithromycin

GI upsets, hepatic dysfunction, QT elongation
CYP450 inhibition
(not azithromycin)

Answer 7

Macrolides