Serotonin, ergot alkaloids, and migraine

Question 1

5-HT is

Answer 1

serotonin

Question 2

Serontonin/5-HT metabolized by

Answer 2

Monamine Oxidase

Question 3

90% of 5-HT is found in the

Answer 3

Enterochromaffin cells in the GI tract

Question 4

Effects of the 5-HT in the nervous system

Answer 4

sleep
sensory perception
motor activity
temp reg
VOMITING
Chemoreceptor reflex

Question 5

Effects of 5-HT in the Pulmonary

Answer 5

Small stimulatio of the bronchiolar smooth muscle

Stimulates ACh release from the brochial vagal nerve

Question 6

Effects of 5-HT in the Cardio

Answer 6

Vasoconstriction except skeletal muscle and heart

Stimulates Platelet Activation

Question 7

Effects of GI tract

Answer 7

stimulant of smooth muscle

Question 8

Carcinoid tumors that produce serotonin can cause

Answer 8

diarrhea

Question 9

Buspirone is a 5-HT1a partial agonist (antagonist in the

Answer 9

anxiolytic

Question 10

What is a 5-HT2C agonist that was withdrawn because of possibility of toxicity/serotonin syndrome

Answer 10

Dexfenfluramine

Question 11

5-HT1B/D agonists treat migraines by constricting

Answer 11

cerebral and meningeal vessels (Sumatriptans)

Question 12

GI Hypermotility 5-HT4 agonists

Answer 12

Cisapride or Tegeserod

Tx: IBD w/ constipation

Question 13

5-HT receptor Antagonists used to treat what sort of tumors

Answer 13

Carcinoid

Question 14

What is both a 5-HT Receptor Antagonist as well as an alpha nonselective antagonist?

Answer 14

Phenoxybenzamine

Question 15

What 5-HT2 antagonist and H1 Receptor Antagonist is used for the treatment of Serotonin Syndrome

Answer 15

Cyprohepatidine

Question 16

Htn, hyperreflexia, tremor, clonus, hyperthermia, hyperactive bowel sounds, diarrhea, mydriasis, agitation, coma onset within hours

Answer 16

Serotonin Syndrome

Question 17

Ergot Alkaloids can be of two Varieties

Answer 17

Catecholamine-like or Serotonin Like

Question 18

Lysergic Acid is a type of

Answer 18

Ergot Alkaloid

Question 19

What ergot alkaloid can promote dopamine release thus treating prolactinoma

Answer 19

Bromocriptine

Question 20

Ergot Smooth Muscle stimulant to limit post-partum hemorrhage

Answer 20

Ergonovine

Question 21

Overuse of non-selective (NSAIDs etc) can cause transformed migraines which indicates

Answer 21

chronic and more painful headaches from sensitization

Question 22

Migraine-Specific therapy

Answer 22

Ergotamine, Dihydroergotamine (low bioavailability)

Question 23

Triptans are agonists of the 5-HT

Answer 23

5-HT1D