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IC > Part II: Drugs of Abuse > Flashcards

Part II: Drugs of Abuse Flashcards

1
Q

cocaine has a short duration of action, it inhibits

A

Dopamine reuptake

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2
Q

Cocaine stimulation of ________ system contributes to reinforcing of euphoric effects and addictive potential

A

Mesolimbic dopamine system

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3
Q

Cocaine is what class of drug?

A

Class II

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4
Q

Drugs of abuse that are stimulants are

A

Cocaine
Amphetamine
Methamphetamine
Methylenedioxymethamphetamine

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5
Q

Drugs of abuse that are psychedelic hallucinogens are

A

Lysergic Acid Diethylamide

Mescaline
Psilocybin

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6
Q

Dissociative hallucinogens are

A

Phencyclidine

Ketamine

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7
Q

Major active compounds in cannabinoids:

A

delta9-Tetrahydrocannabinol

Cannabidiol

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8
Q

Methamphetamine vs d-amphetamine

A

Meth is longer acting and with more pronounced effects

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9
Q

MDMA is an amphetamine with more ________activity

A

serotonin

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10
Q

Adverse effects of MDMA

A

dose-dependent jaw clenching, tachycardia, muscle aches, serotonin syndrome, depression, increased aggression

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11
Q

Hallmark in perception of time with psychadelic hallucingoens

A

time distortion

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12
Q

Mechanism of the Psychedelic Hallucinations

A

Alters cognition and perception by acting on serotonergic system

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13
Q

Dissociative hallucinogens have a specific mechanism of action. what is it

A

Noncompetitive NMDA antgonist

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14
Q

high doses of PCP can cause what adverse effects?

A 
Coma
Muscle Rigidity
Hyperthermia
Seizures
Chronic exposure: long-lasting psychosis
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15
Q

Which active compound of cannabinoids accumulates in adipose

A

delta9-THC, detectable in urine about 3 weeks after cessation

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16
Q

Which receptors in the CNS do Cannabinoids bind to

A

CB1

17
Q

Cannabidiol are a CB_agonist, CB_ antagonist

A

CB1 agonist

CB2 antagonist

18
Q

Ethanol can be used to treat what types of poisonings

A

Propylene glycol

19
Q

Ethanol pharmocokinetics: can cross

A

BBB

PLacenta

20
Q

Metabolism of ethanol

A

Alcohol dehydrogense NAD+ to NADH then Acetaldehyde to acetate via aldehyde dehydrogenase

21
Q

Treatment if alcoholism

A

Disulfiram
Acamprosate
Naltrexone

22
Q

Disulfiram MOA

A

inhibits conversion of acetaldehyde to acetate (increased levels of acetaldehyde causes toxicity)

23
Q

Acamprosate indication

A

maintaining abstinence in those who have already gone through withdrawals and have been abstinent

24
Q

Naltrexone MOA

A

decrease craving for ethanol

IC (18 decks)

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