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IC > Part II: Dementia, ADHD, Narcolepsy, NM disorders > Flashcards

Part II: Dementia, ADHD, Narcolepsy, NM disorders Flashcards

1
Q

Loss of cholinergic activity in the hippocampus proposed explanation for

A

loss of cognition

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2
Q

Cholinesterase inhibitor used as cognitive enhancer

A

Tacrine
Donepezil (muscle cramps)
Rivastigmine
Galantamine

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3
Q

Non-competitive NMDA antagonist similar to ketamine used in Alzheimers

A

Memantine (usually coadministered w/ AchE inhibitor)

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4
Q

Area of the brain implicated in ADHD pathology

A

dopamine/noradrenergic systems projecting from frontosubcortical brain regions

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5
Q

Narcolepsy is associated w/ decreased expression of ______ in the brain

A

Orexin (hypocretin)

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6
Q

Drugs for ADHD/Narcolepsy

A

Methylphenidate
Dexymethylphenidate
d-Amphetamine
Lisdexamfetamine

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7
Q

Norepinephrine and dopmine re-uptake inhibitor that increases glutamatergic activity and decreases GABAergic activity to treat ADHD/Narcolepsy

A

Modafenil
Armodafinil

both class IV drugs

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8
Q

Non stimulants to treat ADHD

A

Atomoxetine

Gaunfecine

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9
Q

anti-spastic

A 
Diazepam
Baclofen (GABA-B agonist, intrathecal)
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10
Q

alpha 2 adrenergic agonist used as an anti-spastic

A

Tizanidine

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11
Q

Drug that acts on muscles that decrease Ca2+ release from the SR

A

Dantrolene

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12
Q

Drug that inhibits Ach release from vesicles in muscle used as an antispastic

A

Botulinum toxin

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13
Q

Drugs used for the acute treatment of muscle spasm

A

cyclobenzaprine
Carisoprodol
Ophenadrine

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IC (18 decks)

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