Part II: Psychotic

Question 1

Major Tranquilizers are in contrast to the

Answer 1

Benzos and barbs

Question 2

Neuroleptic refers to the tendency of a drug to produce neuro side effects for example

Answer 2

Parkinsonism

Question 3

Type of symptoms that are common in schizophrenia

Answer 3

Negative symptoms more often than positive

Question 4

Heritability of Schizophrenia

Answer 4

50% (identical twin w/ schizophrenia means 50% other twin has it)

Question 5

Important dopamine pathways important in the brain

Answer 5

Mesolimbic

Mesocortical

Question 6

Neurotransmitter that mediates hallucinogenic effects of schizophrenia

Answer 6

5-HT2A and 5-HT2C

Question 7

NMDA neurotransmitter important in exacerbating schizophrenic symptoms

Answer 7

Glutamate (phencyclidine and ketamine)

Question 8

All antipsychotics are ___________ antagonists

Answer 8

D2 dopamine receptor antagonists

Question 9

What types of symptoms are improved with antipsychotics?

Answer 9

Positive symptoms

Question 10

Extrapyramidal effects of anti-psychotics

Answer 10

Dystonia

Akathisia

Parkinsonian symptoms (tremor, rigidity, bradykinesia)

Question 11

Cardiovascular alterations that can occur with anti-psychotics

Answer 11

Prolonged Q-T which can lead to Torsade de Pointes

Question 12

Endocrine alterations w/ anti-psychotics

Answer 12

Increased prolactin release from D2 antagonism

Question 13

Blurred vision and retinitis pigmentosa can be a side effect of

Answer 13

thioridazine

Question 14

Metabolic syndrome, diabetes can be a side effect of

Answer 14

Olanzepine

Question 15

Dantrolene can treat what syndrome that is a side effect of anti-psychotics

Answer 15

Neuroleptic Malignant Syndrome

Question 16

Long term side effects of anti-psychotics

Answer 16

Tardive Dyskinesia (writhing)

Perioral Tremor (rabbit syndrome)

Blood dyscrasias: agranulocytosis w/ clonazapine and some phenothiazines

Question 17

Long Term side effect of clonazapine

Answer 17

Blood dyscrasias (agranulocytosis)

Question 18

Antipsychotics potentiate which drugs

Answer 18

CNS depressants (classically barbs)

Question 19

What Typical (older) antipsychotics are tricyclic

Answer 19

Phenothiazines (Chlorpromazine, fluphenazine, thioridazine)

Question 20

what typical antipsychotic is more selective for dopamine receptors than the typical antipsychotics with the highest incidence of EPS that isn’t a phenothiazine

Answer 20

Haloperidol

Question 21

Atypical antipsychotic that does not cause extrapyramidal side effects and antagonist at 5HT2>D2

Answer 21

Clozapine (agranulocytosis)

used for tx resistant psychosis (NEVER FIRST LINE), need blood testing

Question 22

Other Newer 5HT2 antagonists w/ EPS at high dose

Answer 22

Risperidone 5HT2=D2

Lurasidone 5HT2, D2, 5HT7

Question 23

5HT2 antagonists with less EPS

Answer 23

Olanzapine
Quetiapine
Ziprasidone
Aripiprazole