Katzung: Tx Asthma

Question 1

Short Acting Beta-2 agonists promoting bronchodilation

Answer 1

Albuterol (duration 2-4 hours)

Question 2

Short acting beta agonist available PO or parenteral

Answer 2

Terbutaline

Question 3

Adverse effects of Albuterol, the beta-2 selective agonists

Answer 3

Tremor, tachycardia

Question 4

Metaproteranol and terbutaline are also beta 2 agonists used in the treatment of

Answer 4

acute asthma attack

Question 5

Long Acting Beta-2 selective agonists

Answer 5

Salmeterol, Formoterol, Indacaterol, vilanterol

Question 6

Nonselective sympathomimetics as an obsolete tx for asthma

Answer 6

Epinephrine, isproteronol

Question 7

Indirect-acting sympathomimetic used as obsolete tx for asthma

Answer 7

ephedrine (releases stored catecholamines causing nonselective sympathetic effects)

Question 8

Methylxanthines block _____

Answer 8

Phosphodiesterase 4 which increases cAMP

Question 9

Methylxanthines such as theophylline have adverse effects related to increasing

Answer 9

Chronotropy, ionotropy, cardiac Output which can increase blood pressure and increase risk of arrythmias

Also increases gastric acid secretions, digestive enzymes

Question 10

methylxanthines are also weak

Answer 10

diuretics leading to increased GFR and decreased Na reabsorption

Question 11

Theophylline can also be toxic to the

Answer 11

liver

Question 12

Muscurininc Antagonists end in ——- and some examples include

Answer 12

-tropium

ipratropium, tiotropium, aclindinum

Question 13

Muscarinic antagonist that comes as a nasal spray/INH

Answer 13

ipratropium

Question 14

Muscarinic antagonist that is used to treat asthma that has longer duration of action

Answer 14

Tiotropium

Question 15

Muscarinic antagonist that provides bronchodilation lasting about 5 hours

Answer 15

atropine

Question 16

INH corticosteroids that inhibits PLA2 and reduces expression of COX

Answer 16

Beclamethasone, lasts 10-12 hours

Question 17

Systemic Corticosteroid that is like inhaled but is used for the tx of severe refractory chronic asthma and has a DOA of 12-24 hours

Answer 17

Prednisone

Question 18

Parenteral steroid used for status asthmaticus

Answer 18

Prednisolone

Question 19

Why are Leukotriene antagonists used for the treatment of asthma

Answer 19

LTB4 attracts eosinophils, PMNs, Monocytes also decrease contractility, coronary blood flow, recruitment of PMNs in the GI, and promote bronchoconstriction and chemotaxis of eos

Question 20

Leukotriene antagonist that blocks the LTD4 receptor

Answer 20

Montelukast and zafirlukast (oral)

Question 21

Leukotriene antagonist that blocks 5-Lipooxygenase

Answer 21

Zileuton

Question 22

Zileuton toxicity

Answer 22

elevation of liver enzymes

Question 23

Omalizumab is a parenteral Anti-IgE Mab that prevents

Answer 23

mast cell degranulation

Question 24

Mepolizumab and Reslizumab is an Anti-IL

Answer 24

Anti-IL-5, prevents IL-5 from binding to mast cells

Question 25

Prophylaxis that prevents mast cell degranulation by altering delayed chloride channels in cell membranes

Answer 25

Cromolyn, Nedocromil

Question 26

cAMP promotes

Answer 26

bronchodilation

Question 27

Adenosine and ACh promote bronchial tone and cconsequent

Answer 27

bronchoconstriction