nephrotic/nephritic/GMN/Goodpastures

Question 1

5 S&S of nephrotic syndrome

Answer 1

heavy proteinuria
hypoalbuminemia
edema
hyperlipidemia
lipiduria

Question 2

S&S of nephritic syndrome

Answer 2

hematuria
RBC casts in urine
elevated BUN/SCr
decreased GFR
HTN
oliguria
fluid retention/mild edema

Question 3

what disease is 70% of nephrotic syndrome in children

Answer 3

Minimal Change Disease

Question 4

nephrotic syndrome is #1 cause of what in adults

Answer 4

membranous GMN

Question 5

nephritic syndrome is #1 cause of what

Answer 5

acute post-infectious GMN

Question 6

nephrotic syndrome’s etiology related to what diseases

Answer 6

systemic diseases (DM, amyloidosis, SLE)

Question 7

permeability defect in glomerular capillaries allows proteins to be lost from plasma into urine

Answer 7

nephrotic syndrome

Question 8

injury of glomerular capillaries leading to hematuria and mild proteinuria

Answer 8

nephritic syndrome

Question 9

marked hypercellularity of glomerulus

Answer 9

APS-GMN

Question 10

immune-mediate inflammatory glomerulopathy that occurs 1-2 weeks after strep throat or infection with GABHS

Answer 10

APS-GMN

Question 11

what do you see on EM for APS-GMN

Answer 11

subepithelial dense deposits shaped like humps on epithelial side of BM

Question 12

what do you see on IF for APS-GMN

Answer 12

granular deposits (lumpy bumpy) for both IgG and complement along BM

Question 13

smoky colored urine associated with which infection

Answer 13

APS-GMN

Question 14

autoimmune with formation of antibodies to body’s BM membrane components, collagen type 4

Answer 14

goodpasture’s syndrome

Question 15

what do you see on IF for goodpasture’s syndrome

Answer 15

linear deposits in glomerulus - ribbon

Question 16

crescents that compress capillary loops can lead to what

Answer 16

RPGMN

Question 17

fusion of visceral epithelial foot processes

Answer 17

minimal change disease

Question 18

what disease has no glomeruli changes or the glomeruli contains no deposits of IgG on both LM and IF

Answer 18

minimal change disease

Question 19

devoid of RBCs

Answer 19

membranous GMN

Question 20

what does LM show for membranous GMN

Answer 20

glomeruli with thickened BM and normocellular

Question 21

what does EM show for membranous GMN

Answer 21

thickening of BM attributed to deposition of dense immune complexes

Question 22

what does IF show for membranous GMN

Answer 22

granularity deposits of IgG

Question 23

how do you treat minimal change disease

Answer 23

corticosteroids

Question 24

how do you treat membranous GMN

Answer 24

corticosteroids