Bacteria and human health Flashcards
How many bacteria compose the human body?
40 trillion
What kind of relationship can bacteria and host have?
Parasitic
Symbiotic
Free-living
What happens to a newborn?
Colonisation.
Newborn is subjected to new bacteria through the environment around it.
The environment around it will therefore affect the microbiota that colonises the body.
There are various different species that compete for the same body surface.
When do communities develop?
With age
Depend on the environment of the host
In disease the populations will change
What are the characteristics that alter the parameters of the skin?
pH Temperature Moisture Nutrient content Shear
What are the characteristics that affect colonization by cutaneous microbes?
Temperature
Moisture
Glandular disrtribution
Occlusion of the region
Description of skin
Mostly dry
Secretions have high osmolarity
Lipid content changes throughout the body
Temperature changes throughout the body
Temperature is lower than internal organs
Aerobic environment
pH is usually acidic
What is the average amount of sweat produced per day
200 ml
What glands produce this sweat
Eccrine glands
Where is the bacterial population respectively highest?
In the GI tract
The bigger the organ, the larger the bacterial population
What sort of relationship is there between the host and microbiota?
Multidirectional chemical communication between host cellular pathways and microbial species/ communities/ activities
Host-microbe metabolic axes
What does the microbiota participate in?
Metabolism of food products
Production of growth factors
Protection against infection - colonisation resistance
Stimulation of the immune system
What diseases are related to microbiota dysregulation?
Ulcerative colitis
Schizophrenia
Obesity
Autism
