1. B Cell-Mediated Immunity

Question 1

What chemokine attracts immature B cells to HEV?

Answer 1

CCL21

Question 2

What chemokines attract B cells into lymph nodes?

Answer 2

CCL21

CCL19

Question 3

What Chemokine attracts B cells into primary follicle?

Answer 3

CXCL13

Question 4

Interatction with ____ and cytokines produces mature Naive B cells

Answer 4

follicular dendritic cells

Question 5

Activation of B cells cause 3 things. what is it?

Answer 5

Clonal expansion
Class switching
Somatic hypermutation

Question 6

What are the 2 antigen type signaling for B cell activation?

Answer 6

1. Thymus-dependent

2. Thymus-independent

Question 7

What are the three signals for B cell Activation?

Answer 7

1. Antibody Crosslinking -activates
2. Co-receptor - survival and proliferation
3. Signaling
   Cytokines - Differation, SHM, switch class
   (1 & 2 are requisite)

Question 8

When an Antibody is bound to an antigen (AKA Antibody crosslinking) what occurs? (3)

Answer 8

1. Clustering/aggregation
2. IGa and IGB signaling
3. ITAM phosphorylation for recruitment

Question 9

What does B Cell Co-receptor signaling ensure?

Answer 9

That the Target is pathogenic

Question 10

What are the four roles of Cytokine Signaling?

Answer 10

1. Survival and proliferation
2. Class switching
3. Somatic Hyper-mutation
4. Differentiation

Question 11

Naive T cells look for

Answer 11

Dendritic cells

Question 12

Naive B cells look for

Answer 12

Follicular Dendritic cells found in the primary follicle

Question 13

What is the most common B cell activation pathway?

Answer 13

TFH Cells Aid in B Cell Activation

Question 14

Name the steps of TFH cell Aid in B Cell Activation. (4)

Answer 14

1. B Cell binds to antigen
2. B Cell presents to TFH
3. CD40 induces proliferation and survival
4. Cytokines cause Differantion and Isotype Switching

Question 15

Where do Cognate pairs first move?

Answer 15

Primary Focus

Question 16

What happens at the Primary Focus? (2)

Answer 16

1. IgM expressing of plasma cells

2. No class switching nor hyper mutation

Question 17

After the Primary Focus where do the cognate pairs move to and what occurs?

Answer 17

Secondary Focus to form Germinal Centers

Question 18

What happens at 2nd Focus/ germinal Centers? (3)

Answer 18

1. Proliferation & Plasma/memory cell production
2. Class switching
3. Selection of plasma cells

Question 19

In Germinal centers cognate pairs form….?

Answer 19

Centroblasts

in the dark zone

Question 20

Centroblasts create

Answer 20

centrocytes

Question 21

What do Centroyctes form?

Answer 21

Plasma and B memory cells

in the light zone

Question 22

Name somethings of Class switching (3)

Answer 22

1. RAG activation
2. change of Heavy chain
3. Cytokine induced

Question 23

What cell has a high- rate of Ig Secretion?

Answer 23

Plasma Cell

Question 24

What are the 4 broad effector functions of Antiboies?

Answer 24

1. Virus/toxin neutralization
2. Opsonization
3. Complement
4. Antibody-dependent Cell-mediated CYtotoxicity (NK Cells)

Question 25

What Antibodyies do you find in internal tissues?

Answer 25

IgM
IgG
IgA

Question 26

What Antibodyies do you find in mucosal surfaces?

Answer 26

IgA

Question 27

What Antibodyies do you find for parasite immunity?

Answer 27

IgE

Question 28

What Antibodyies do you find for B cell receptor?

Answer 28

IgD

Question 29

What does Fc receptors allow?

Answer 29

enhance innate immune cell specificity & function

Question 30

What causes binding and unbinding of IgG w. FcRn?

Answer 30

pH lvls

Question 31

Common antibodies for neutralizing pathogens?

Answer 31

IgA

IgG

Question 32

Which antibodies Makes Mast Cells, Basophils and Eosinophils Competent?

Answer 32

IgE (important in allergies)

Question 33

Which Antibodies initiate the Classical Complement pathway?

Answer 33

IgM

IgG