neuropharm Flashcards

1
Q

What does botox do and what is it used for?

A

Prevent Ach release at alpha motor neuron

Spasticity
Migraine
Dystonia
abnormal eye movement

starts working 48-72 hrs.

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2
Q

What is baclophen and what is it used for?

A

bind to GABA
block Ca from coming to presynaptic terminal -> reduce NT release and hyperpolarization

used for spasticity
SCI
MS

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3
Q

Patho of alzheimers?

A

excess tau/ inadequate clearance.
excess amyloid production

there is brain shrinkage/ loss of cholinergic neuron in frontal cortex
amyloid plaque
neurofibrillary tangles. all from tau.

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4
Q

Tx of Alzheimers?

A

block Ach-ase to make more Ach. present.

via:
AchEI
Glutamade modulator: antagonize NMDA
Behavior treatment: environemtn/mood (SSRI) .agitation.(neuroleptic)

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5
Q

L-Dopa/ Carbidopa?

A

replace Dopamine

inhibit conversion of Ldopa to Dopamine outside of Brain.

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6
Q

Antichollinergic

A

Dec CNS Ach. and Tresore balance of Dopamine and Ach.

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7
Q

Different between L-dopa and Dopamine?

A

Pure dopamine won’t cross BBB but L-dopa will

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8
Q

Why is Carbidopa added to L dopa?

A

Carbidopa inhibities enzymes that break down L-dopa.

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9
Q

Side effects of AEDs?

A

Sedation
Drowsy
Depressed
Dizzy

that can be used to treat bipolar
neuropathic pain
migraine.

AED is antiepilleptic used for seizure.

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10
Q

Positive screening test for Intrathecal baclofen?

A

Drop in spasticity scale

hypotonia w/o resp. difficulty.

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11
Q

What are ways to treat parkinson’s?

A

Dopamine agonist
L-dopa w/ carbidopa
Anticholinergics.

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