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HIGH YIELD > Therapeutic Antibodies + Cytokines p.117-118 > Flashcards

Therapeutic Antibodies + Cytokines p.117-118 Flashcards

1
Q

Alemtuzumab

A

Target: CD52

Tx: CLL, MS

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2
Q

Bevacizumab

A

Target: VEGF

Tx: Colorectal Cancer, Renal Cell Carcinoma, Non-Small Cell Lung Cancer

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3
Q

Cetuximab

A

Target: EGFR

Tx: Stage IV Colorectal Cancer, Head and Neck Cancer

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4
Q

Rituximab

A

Target: CD20

Tx: B-Cell non-Hodgkin Lymphoma, CLL, Rheumatoid Arthritis, ITP

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5
Q

Trastuzumab

A

Target: HER2/neu

Tx: Breast Cancer, Gastric Cancer

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6
Q

Adamlimumab

A

Target: Soluble TNF-alpha

Tx: IBD, Rheumatoid arthritis, Ankylosing spondylitis, Psoriasis

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7
Q

Certolizumab

A

Target: Soluble TNF-alpha

Tx: IBD, Rheumatoid arthritis, Ankylosing spondylitis, Psoriasis

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8
Q

Golimumab

A

Target: Soluble TNF-alpha

Tx: IBD, Rheumatoid arthritis, Ankylosing spondylitis, Psoriasis

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9
Q

Infliximab

A

Target: Soluble TNF-alpha

Tx: IBD, Rheumatoid arthritis, Ankylosing spondylitis, Psoriasis

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10
Q

Etanercept

A

Not actually a monoclonal antibody.

Acts as a TNF-alpha receptor decoy

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11
Q

Daclizumab

A

Target: CD25 (part of IL-2 receptor)

Tx: Relapsing MS

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12
Q

Eculizumab

A

Target: Complement Protein C5

Tx: Paroxysmal Nocturnal Hemoglobinuria

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13
Q

Natalizumab

A

Target: a4-integrin

Tx: MS, Crohn DIsease

Risk of PML in patients with JC virus

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14
Q

Ustekinumab

A

Target: IL-12/IL-23

Tx: Psoriasis, Psoriatic Arthritis

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15
Q

Abciximab

A

Platelet Glycoproteins IIb/IIIa

Tx: Antiplatelet for patients undergoing PCI

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16
Q

Denosumab

A

Target: RANKL

Tx: Osteoporosis, Inhibits osteoclast maturation (mimics Osteoprotegrin)

17
Q

Digoxin Immune Fab

A

Antidote for Digoxin Toxicity

18
Q

Omalizumab

A

Target: IgE

Tx: Refractory Allergic Asthma
Prevents IgE binding to FceRI

19
Q

Palivizumab

A

Target: RSV F Protein

Tx: RSV Prophylaxis for high-risk infants

20
Q

Ranibizumab

Bevacizumab

A

Target: VEGF

Tx: Neovascular age-related macular degeneration
Proliferative Diabetic Retinopathy
Macular Edema

21
Q

Aldesleukin (IL-2)

A

Renal Cell Carcinoma

Metastatic Melanoma

22
Q

Epoetin alfa

A

Anemias (esp in Renal failure)

23
Q

Filgrastim (G-CSF)

A

Recovery of bone marrow and WBC counts by GRANULOCYTE stimulation

24
Q

Sargramostim (GM-CSF)

A

Recovery of bone marrow and WBC counts by GRANulocyte and MONocyte stimulation

25
Q

IFN-alpha

A 
Chronic Hep B/C
Kaposi Sarcoma
Malignant Melanoma
Hairy Cell Leukemia
Condyloma acuminata (HPV)
Renal Cell Carcinoma
26
Q

IFN-beta

A

Multiple Sclerosis

27
Q

IFN-gamma

A

Chronic Granulomatous Disease

28
Q

Romiplostim, Eltrombopag

A

Thrombocytopenia

Thrombopoietin analogs/receptor agonists

29
Q

Oprelvekin (IL-11)

A

Thrombocytopenia

HIGH YIELD (21 decks)

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