Pain/MSK Drugs

Question 1

NSAID examples

Answer 1

Diclofenac, Aspirin, Ibuprofen, Indomethacin

Question 2

How do NSAIDs work?

Answer 2

Blocks COX enzymes = Reduces production of prostaglandins

Question 3

Why doe NSAIDs lead to bleeding/ulcers?

Answer 3

Block COX 1 which is protective of stomach and promotes clotting

Question 4

NSAIDs Contraindications

Answer 4

Peptic Ulcer/Stomach bleeding, Hypertension, Kidney disease, IBD

Question 5

What do NSAIDs do to Blood Pressure?

Answer 5

Increase it

Question 6

NSAID Interactions

Answer 6

Decreases elimination of lithium and methotrexate = toxicity

Increased risk of bleeding with warfarin etc

Diuretics - Reduce blood flow to kidneys

Question 7

Opiate examples

Answer 7

Codeine, Morphine, Heroin, Oxycodone, Fentanyl

Question 8

Opiate Side Effects

Answer 8

Respiratory depression + Bronchospasm, Itchiness, Constipation

Question 9

Example of a Non-Opioid

Answer 9

Paracetamol

Question 10

Paracetamol Containdications

Answer 10

Liver problems, Renal impairment, Shock