Urology Drugs

Question 1

Examples of Alpha-Blockers

Answer 1

Doxazosin, Tamsulosin, Alfuzosin

Question 2

What receptors do Alpha-Blockers work on and where are they found?

Answer 2

a1-adrenoreceptors

Found in Blood Vessles and Urinary Tract

Question 3

How do Alpha-Blockers work?

Answer 3

Block a1-adrenoreceptors = relaxation, vasodilatation, reduces resistance to bladder outflow

Question 4

Alpha-Blockers Indications

Answer 4

First line to improve BPH symptoms

Add on treatment for resistant Hypertension

Question 5

Alpha-Blockers Contra-indications

Answer 5

Postural Hypotension

Question 6

Alpha-Blockers Side-effects

Answer 6

Hypotension, Dizziness, Syncope

Question 7

5-Alpha Reductase Inhibitors Examples

Answer 7

Finasteride, Dutasteride, Epristeride

Question 8

How do 5 Alpha Reductase Inhibitors work?

Answer 8

Reduce size of prostate by inhibiting enzyme which converts testosterone to DHT

(DHT stimulates prostatic growth)

Question 9

5 Alpha Reductase Inhibitors Indications

Answer 9

Second-line for BPH to improve symptoms

Question 10

5 Alpha Reductase Inhibitors Contra-indications

Answer 10

Pregnancy ( =abnormal genitalia of male foetus)

Question 11

5 Alpha Reductase Inhibitors Side Effects

Answer 11

Anti-androgen action = Impotence, Reduced libido, Breast tenderness/enlargement, Breast cancer