Anti-inflammatory (Systemic and local)

Question 1

Contra-indications for NSAIDS?

Answer 1

Active GI Bleeding or Ulceration or history of either
Cerebrovascular disease
History of NSAID related GI bleeding
Ischaemic Heart Disease
Mild or Severe Heart Failure
Peripheral Arterial Disease

Question 2

Common Side effects of NSAIDS

Answer 2

GI Ulcers
Worsening Asthma
Impaired Renal Function

Question 3

Indications for NSAIDs

Answer 3

Inflammatory pain

Question 4

Indications for Prednisolone?

Answer 4

Oral - Exacerbation of COPD

REctal - Ulcerative Colitis

Question 5

Prednisolone Contra-Indications?

Answer 5

Avoid injections containing benzyl alcohol in neonates
Live vaccines (immune suppressive doses)
Systemic Infection
Avoid along in the presence of untreated ear infection (combine with suitable ant-infective)
Bowel Perforation (Rectal)
Extensive Fistulas
Recent intestinal anastamoses

Question 6

Common Side effects of prednisolone?

Answer 6

Osteoporosis
Diabetes
Avascular necrosis of the femoral head (high doses)
Muscle wasting
Psychiatric reactions

Question 7

Is it safe to abruptly stop treatment of prednisolone?

Answer 7

Not for certain patient groups as can lead to renal insufficiency

If disease is unlikely to relapse and t/ment received for less than 3 weeks and not part of specific patient groups mentioned in BNF then abrupt withdrawal is ok

Question 8

What are ICS used to treat?

Answer 8

Asthma - improve control/reduce frequency of exacerbations

Severe/very severe COPD - reduce frequency of exacerbations

Question 9

Are there any contra-indications to ICS?

Answer 9

No

Question 10

Common side effects of ICS?

Answer 10

Oropharyngeal candiadis
headache
hoarseness (Dysphonia)
sore throat

Question 11

Can ICS be stopped abruptly?

Answer 11

Usually need to reduce dose gradually

Question 12

What organ do NSAIDs sometimes negatively affect and why?

Answer 12

Kidneys

Some prostaglandins in COX-1 pathway effects pressure of blood flow through Kidneys