LUPUS ERYTHEMATOSUS

Question 1

To make a diagnosis of SLE according to SLICC 2012:

Answer 1

• ≥ 4 criteria (at least 1 clinical and 1 immunologic) are required.

Question 2

TTT of mild course of SLE?

Answer 2

• Antimalarial drugs (chloroquine)
• Glucocorticosteroids – low doses
• Methotrexate

Question 3

What is the most common complain in SLE?

Answer 3

Arthralgia.

Question 4

Common signs of all types of lupus :

Answer 4

• Presence of skin lesions
• Hypersensitivity to UV
• Immunoglobulin deposits at the dermoepidermal junction (lupus band)

Question 5

Raynaud’s phenomenon is:

Answer 5

• ”Cold hands syndrome”
• A paroxysmal vasospasm within hands (less commonly in feet, nose, ears). It is triggered by exposure to low temperature, stress or it may occur spontaneously.
• 5-10% of population, predominantly young women.

Question 6

Stippling sign?

Answer 6

In DLE, erythematous discoid plaques with adherent scales over dilated pilosebaceous orifices.

Question 7

Diagnosis of DLE ?

Answer 7

• Clinical presentation
• Histopathology
• Ig deposits at the dermoepidermal junction (lupus band test)

Question 8

What is the exception to SLE diagnostic criteria:

Answer 8

That histopathologically confirmed lupus nephritis plus antinuclear antibodies or anti-dsDNA.

Question 9

TTT of DLE and SCLE ?

Answer 9

• DOC: Antimalarial drugs (chloroquine)
• Others: Glucocorticosteroids(topically), immunosppressive.
• SCLE may need more intensive systemic ttt.

Question 10

DLE clinical presentations ?

Answer 10

• sharply marginated foci “erythema”
• erythemato-““infiltrated”” follicular
• Follicular hyperkeratosis
• scarring alopecia.

Question 11

Lesion sites in DDLE (Disseminated Discoid Lupus Erythematosus) ?

Answer 11

Neck, trunk and arms.

Question 12

Subacute cutaneous lupus erythematosus (SCLE) antibodies?

Answer 12

• Anti-Ro antibodies in approx. 80% of cases
• Does not meet the criteria of SLE diagnosis, but systemic pathologies
  may be present.

Question 13

SYSTEMIC LUPUS ERYTHEMATOSUS (SLE) is :

Answer 13

A chronic autoimmune disease occurring with cutaneous and multiorgan involvement.

Question 14

Subacute cutaneous lupus erythematosus (SCLE) lesions ?

Answer 14

• ring-shaped.

- psoriasiform.

Question 15

SLE criteria :

Answer 15

SOAP BRAIN MD

name it

Question 16

In drug-induced SLE which antibodies we have?

Answer 16

Anti-histone.

Question 17

Which antibodies is responsible for neonatal lupus ?

Answer 17

Anti-Ro and anti-La antibodies.

• these antibodies are also:
• 30% of patients with SLE, but also in Sjogren’s syndrome
• hypersensitivity to UV

Question 18

TTT of High activity of SLE?

Answer 18

- Glucocorticosteroids
(orally or IV pulse therapy) 
- Cyclophosphamide
- Mycophenolate mofetil 
- Cyclosporine
- Belimumab 
- Rituximab

Question 19

Subacute cutaneous lupus erythematosus (SCLE) may mimic ?

Answer 19

psoriasis

Question 20

Lesion sites in DLE ?

Answer 20

Mainly on the exposed body parts: face, nose, ears and scalp.