Lymphoma

Question 1

Pruritus in Large plaque parapsoriasis – poikilodermic variant is a symptom of ?

Answer 1

malignant transformation !!!

Question 2

Clinical stages of Mycosis fungoides?

Answer 2

- Phase 1: Patch stage
Persistent scaly patches.
- Phase 2: Plaque stage
Infiltrative elevated lesions.
- Phase 3: Tumor stage
nodules

Question 3

Which Parapsoriasis is with high risk of malignant transformation?

Answer 3

• Large-plaque parapsoriasis.
• Poikiloderma atrophicans vasculare.
• And MF can develop in 20% of cases.

Question 4

T cell lymphomas of

the skin are ?

Answer 4

• mycosis fungoides.
• Sezary syndrome.
• Pagetoid reticulosis.

Question 5

Mycosis fungoides diagnosis ?

Answer 5

• clinical skin changes +
• histopathology (collections of lymphocytes
  (Pautrier microabscess) 25%)

Question 6

Mycosis fungoides treatment?

Answer 6

_accordingly to the stage of the disease:

• Topical: moderate to potent corticosteroids, bexaroten, carmustine
• Phototherapy: PUVA, Re-Puva, NB-UVA
• Oral retinoids (baxaroten, acitretin)

Question 7

Mycosis fungoides is :

Answer 7

T cell lymphoma

Question 8

Large-plaque parapsoriasis biopsy ?

Answer 8

• consider repeated biopsies, every six months.

- Pruritus!!! and elevation as indicators of transforamtion.

Question 9

What is the risk of malignant transformation in Actinic keratoses?

Answer 9

10%

Question 10

Which Parapsoriasis form does not progress to lymphoma?

Answer 10

Small-plaque parapsoriasis

Question 11

Which erythrodermic leukemic manifestation

of T-cell lymphoma whith worse prognosis than MF?

Answer 11

• Sezary syndrome.

5-yr survival – 10-20%

Question 12

Three symptoms – classic triad of Sezary syndrome?

Answer 12

• Erythroderma.
• Lymphadenopathy.
• Atypical lymphocytes Circulating in the blood.