61. Anti-viral

Question 1

Inhibition of viral uncoating

Answer 1

Ion channel blockers: M2 ion channel blocked
> Amantadine
- Influenza A
- NMDA antagonist +anti-cholinergic

Question 2

Inhibition of viral NA replication

Answer 2

Polymerase inhibitors

1. Pyrimidine analogues:
   
   • Idoxuridine
   • Trifluridine
   • Cidofovir
2. Purine analogues
   
   • Acyclovir (needs phosphorylation by kinase)
   • famciclovir
   • ganciclovir
3. Zidovudine (AZT)
   
   • No conversion of RNA to DNA

Question 3

Inhibitors of viral release

Answer 3

Neuroaminidase inhibitors

• Zanamivir
• oseltamivir

Question 4

Interferons

Answer 4

Enhance immune response, not act on virus its self
> INF alpha: Hepatits, human papilloma
> INF Beta: MS
> INF gamma: T-cells
> Feline recombinant INF omega