Dyslipidemia agents Flashcards
1
Q
What is the most potent statin?
A
Atorvastatin (lipitor)
50-60% Cholesterol reduction (LDL reduction)
it ALSO has the most potent Triglyceride lowering effects.
AND
the most potent HDL increase, 5-15%. (the others are 5-10%)
2
Q
What are the current commonly used statins
A
Atrovastatin
Lovastatin
Simvastatin
3
Q
What are the old statins
A
Fluvastatin
Pravastatin
4
Q
Target of the statins
A
HMG-CoA Reductase
5
Q
How are statins metabolized
What is the exception
A
They are all CYP substrates, metabolized by the liver.
Rosuvastatin is only minimally metabolized by the liver, mostly excreted unchanged into feces.
