drugs for Neurodegenerative disorders

Question 1

Parkinsons drugs

Answer 1

Pramipexole
Ropinirole
Bromocriptine

Levodopa

Carbidopa

Entacapone and Tolcapone

Amantidine

Benztropinbe and Trihexyphenidyl

Question 2

Alzheimer’s drugs

Answer 2

Galantamine, Rivastigmine, Donepezil, and Tacrine

Memantine

Nootropics

Question 3

Nootropic drugs

Answer 3

1. Piracetam
   - Unclear mechanism, may increase AMPA signaling,
   ADh signaling
   - Decreases platelet aggregation
   - Stimulates cerebral vasodilation
2. Nicergoline
   Ergot derivative alpha inhibitor, increased blood flow

3.Ginkgo biloba and other antioxidants: Vitamin C, E

4. Nimodipine
   CCB, increased cerebral blood flow
5. Trophic factors: NGH

Question 4

Drug for AML

Answer 4

• Riluzole – Na channel blocker, increases survival 2 months

Question 5

Drugs for Wilson’s disease

Answer 5

Excessive copper accumulation

• Rx: D-Penicillamine, Trientien –Copper chelators,