Drugs For Asthma

Question 1

Short acting beta 2 agonist
DOC for acute asthma
May precipitate arrhythmia in pxs with concurrent COPD and heart disease

Drug?

Answer 1

Albuterol/Salbutamol

Levalbuterol, Terbutaline, Metaproterenol, Pirinuterol, Procaterol, Fenoterol

Question 2

Long acting beta 2 agonist
Drug for asthma prophylaxis and potentiation of corticosteroid action
Increases asthma mortality when used alone
May precipitate arrhythmia in pxs with concurrent COPD and heart disease
No role in acute attacks

Drug?

Answer 2

Salmeterol

Formoterol, Cleneterol, Bambuterol

Question 3

Muscarinic receptor antagonist
Prevents vagal stimulated bronchoconstriction
Drug for asthma, COPD
SE: dry mouth
More effective and less toxic than Beta agonists in pxs with COPD

Drug?

Answer 3

Ipratropium

Tiotropium

Question 4

Methylxanthine
Inhibits phosphodiesterase, adenosine receptor antagonist, causes bronchodilation
Drug for prophylaxis of nocturnal asthma attack
Narrow therapeutic window

Drug?

Answer 4

Theophylline
(Aminophylline, Pentoxyfylline: also for intermittent claudication)

LAHAT NG -YLLINE

Question 5

Antidote for Theophylline overdosage

Class?

Answer 5

Beta-blockers

Question 6

Mast cell stabilizer
Prevents degranulation
Drug for asthma prophylaxis
No bronchodilator action, no role in acute attacks

Drug?

Answer 6

Cromolyn sodium

Question 7

Inhibitor of Phospholipase A2, reduces cyclooxegenase expression
DOC for asthma prophylaxis, COPD, allergic rhinitis
SE: oropharyngeal candidiasis, mild growth retardation

Drug?

Answer 7

Fluticasone

Beclomethasone, Budesonide, Ciclesonide, Flunisolide, Mometasone, Triamcinolone

Question 8

Which corticosteroid is used for tx of Status Asthmaticus?

Answer 8

IV Hydrocortisone

Question 9

Which corticosteroid has lowest systemic steroid toxicity?

Answer 9

Ciclesonide

Question 10

Leukotriene synthesis inhibitor
Drug for asthma prophylaxis
SE: elevation of liver enzymes
No bronchodilator action

Drug?

Answer 10

Zileuton

Question 11

Leukotriene antagonist
Drug for asthma prophylaxis
Rare SE: Churg-Strauss Syndrome
No bronchodilator action

Drug?

Answer 11

Montelukast

Zafirlukast, Pranlukast

Question 12

Severe asthma with increased eosinophil count and eosinophilic deposits in the small vessels of the lungs

Disease?

Answer 12

Churg-Strauss Syndrome

Question 13

Binds IgE antibodies on mast cells, reduces reaction to inhaled antigen
Drug for prophylaxis of severe, refractory asthma that is unresposive to all other drugs
EXPENSIVE!

Answer 13

Omalizumab, Monoclonal Antibody, Anti-IgE

Question 14

IV corticosteroids are only used as relievers for this kind of asthma

Answer 14

Status Asthmaticus