L1 Genes --> Cell --> Behaviour Flashcards
What is one of the fundamental problems with development
How do chromosomes which are identical in all of the cells - direct differences in the cells
What are the two hypotheses which explain the restriction of a cells potency
Gene loss
Differential gene activity
What evidence is there to suggest that differential gene expression is the correct hypothesis
Gene expression in differentiating cells can be changed
Gene expression in cell can be changed by factors within that cell or from other cells
Genes are not lost when cells differentiate
What is cell intrinsic signalling?
Factors from cell 1 acting on cell 1
What is cell extrinsic signalling
Factors from cell 2 acting on cell 1
What is cell autonomous signalling also known as
Cell intrinsic
What is cell non autonomous signalling also known as
Cell extrinsic
What is cell extrinsic signalling also known as
Cell non autonomous
What is cell intrinsic signalling also known as
Cell autonomous
What can be said about a cells comittment to their fates as development proceeds
Cells gradually become comitted to their fates
What are the generally accepted views with regards to development
Sequential, systematic changes in gene expression
Interactions between the nucleus and the changing cytoplasmic environment
What is the fundamental embryology governing development
Understanding why tissue cells do not express their entire genome
How many stages are involved in the regulation of gene expression
Many
What are enhancers
Activators of transcription found 5’ upstream of the binding site for RNA polymerase
Acts to open up/silence the chromatin
What are transcription factors
Usually act as a complex with other TFs
