Immune Modulators

Question 0

Inhibit lymphocyte proliferation by blocking DNA synthesis

Answer 0

Azathioprine, cyclophosphamide, mycophenolate

Question 1

Block inflammation

Answer 1

Corticosteroids

Question 2

Inhibit calcineurin-dependent activation of NFAT which blocks IL-2 and T-cell proliferation

Answer 2

Cyclosporine A, Tacrolimus (FK506)

Question 3

Inhibits proliferation of effector T cells

Answer 3

Rapamycin

Question 4

Blocks lymphocyte trafficking out of lymphoid tissues

Answer 4

Fingolimod (FTY270)

Question 5

Abs prepared in rabbits or horses that are directed against T cells to prevent graft rejection

Answer 5

Anti-lymphocyte globulin

Question 6

Used to treat some viral diseases due to immune enhancing activity, but also to manage MS by limiting production of IL-1

Answer 6

IFN-β

Question 8

Controlling tumors: Monoclonal abs

Answer 8

Herceptin (breast cancer)- receptor down-regulation

Anti-CD20 (Rituximab) (non Hodgkins B cell lymphoma)- apoptosis of B cells

Question 9

Controlling tumors: Monoclonal abs as immunotoxins

Answer 9

Ricin A chain
Pseudomonas exotoxin A
Adriamycin
Radioisotope

Question 10

2 other ways to control tumors (besides Mabs)

Answer 10

Vaccination

Agent that stimulate immune system to better target tumors