Host defense mechanisms

Question 1

Host defense mchanisms

Anatomic - wound, etc

Answer 1

Indigenous Flora

At site of impairment

Question 2

Host defense mchanisms

Humoral - Ab + complement (Th2/B cell axis)

Answer 2

Encapsulated Bacteria (S pn, N Mg, Hib), GNR, Enterovirus, Giardia

Sinopulmonary tree, meninges, blood, GI

Question 3

Host defense mchanisms

Humoral - Ab ? IgM

Answer 3

GNR, N. Mg

Blood

Question 4

Host defense mchanisms

Humoral - Ab ? IgG

Answer 4

Encapsulated bacteria, enterovirus, giardia

Sinopulmonary tree, meninges, blood

Question 5

Host defense mchanisms

Humoral - Ab ? IgA

Answer 5

Local flora, giardia

Sinopulmonary tree, GI

Question 6

Host defense mchanisms

Humoral - Complement Cascade components

Answer 6

Encapsulated bacteria - esp meningococci

Sinopulmonary tree, meninges, blood

Question 7

Host defense mchanisms

Humoral - Reg Proteins

Answer 7

Encapsulated Bacteria

Sinopulmonary tree, meninges, blood

Question 8

Host defense mchanisms

Phagocytes - Quantitative (<500 PMN/mm3)

Answer 8

GNR, P. aeruginosa, Staph, Fundi (candida, aspergillus)

Blood, lungs, skin

Question 9

Host defense mchanisms

Phagocytes - Qualitative ? normal or increased PMN

Answer 9

S. aureus, GNR, Fungi-aspergillus

Skin, lungs, blood

Question 10

Host defense mchanisms

RES - Spleen

Answer 10

Encapsulated Bacteria

Blood

Question 11

Host defense mchanisms

RES - Liver (drains gut)

Answer 11

Enteric GNR

Blood

Question 12

Host defense mchanisms

Cell Mediated Immunity (Th1/T cell axis)

Answer 12

Intracellular bacteria - salmonella, legionella, listeria, TB
Fungi- cryptococcus
DNA viruses - HSV, CMV
Protozoa - PCP, Giardia, toxoplasmosis
Parasites - strongyloides

Lungs, Meninges, GI, Skin