Pharmacology

Question 1

rate of diffusion is described by which law?

Answer 1

Fick’s Law

Question 2

name the 4 combinations of drugs and bases

Answer 2

lipophilic drug in lipophilic base

lipophilic drug in hydrophilic base

hydrophilic drug in lipophilic base

hydrophilic drug in hydrophilic base

Question 3

which combination of drug and base is best for preferential partitioning into the skin?

Answer 3

lipophilic drug in hydrophilic base

Question 4

the inclusion of __________ in the vehicle can enhance solubility of a drug

Answer 4

excipients

e.g. propylene glycol

Question 5

the greater the __________ of the skin, the better the ____ __ _________ in the skin of the drug

Answer 5

the greater the WATERINESS of the skin, the better the RATE OF DIFFUSION in the skin of the drug

Question 6

name the 2 factors that influence the absorption of topically applied drugs

Answer 6

nature of skin - site hydrations and integrity

drug/pharmaceutical preparation - concentration, salt and vehicle

Question 7

glucocorticoids signal via _______ receptors (class _)

Answer 7

glucocorticoids signal via NUCLEAR receptors (class 1)

Question 8

drugs can be delivered by what to increase duration and effectiveness and provide a constant rate of delivery?

Answer 8

transdermal patches

Question 9

long term use of high ______ steroids can produce serious ______ effects

Answer 9

long term use of high POTENCY steroids can produce serious ADVERSE effects

Question 10

name some drugs that can be delivered via TDPs.

Answer 10

nicotine
GTN
fentanyl
estradiol