Antiemetics - Phenothiazines Flashcards
1
Q
What are phenothiazones used in?
A
- Nausea and vomiting
- Psychotic disorders
2
Q
What is the mechanism of action of phenothiazines?
A
- Blocks D2 receptors in the CTZ
- Blocks D2 receptors in the gut
- Blocks H1 and muscarinic receptors in vomiting centre and vestibular system
3
Q
What types of vomiting are phenothiazines useful for?
A
Broadspectrum
- Chemo
- Radiotherapy
- Vertigo
4
Q
What are side effects of phenothiazines?
A
- Drowsiness
- Postural hypotension
-
Extrapyramidal syndromes
- Acute dystonic reaction/oculogyric crisis
- Tardive dyskinesia
- QT prolongation
5
Q
What are important things to be cautious of when prescribing phenothiazines?
A
- Severe liver disease
- Prostatic hypertrophy
- Elderly
6
Q
What are examples of phenothiazines?
A
- Prochlorperazine
- Chlorpromazine
7
Q
What should you monitor for with chronic use of phenotiazines?
A
Extrapyramidal features
